Antigen-Specific TCR Signatures of Cytomegalovirus Infection

• Published in: The Journal of immunology (1950) Vol. 202; no. 3; pp. 979 - 990
• Main Authors: Huth, Alina, Liang, Xiaoling, Krebs, Stefan, Blum, Helmut, Moosmann, Andreas
• Format: Journal Article
• Language: English
• Published: United States 01.02.2019

CMV is a prevalent human pathogen. The virus cannot be eliminated from the body, but is kept in check by CMV-specific T cells. Patients with an insufficient T cell response, such as transplant recipients, are at high risk of developing CMV disease. However, the CMV-specific T cell repertoire is comp...