Dual functions of the Drosophila eyes absent gene in the eye and embryo

• Published in: Mechanisms of development Vol. 73; no. 2; pp. 193 - 202
• Main Authors: Leiserson, William M, Benzer, Seymour, Bonini, Nancy M
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.05.1998
• Subjects: Animals; DNA, Complementary; Drosophila; Drosophila Proteins; Embryo, Nonmammalian - metabolism; Embryogenesis; Eye - metabolism; Eye development; Eye Proteins - genetics; Eyes absent; Female; Gene Expression Regulation, Developmental; Genes, Lethal; Genetic mosaic; Heterozygote; Male; Mutation; Phenotype; RNA, Messenger - genetics; Embryogenesis; Eye development; Genetic mosaic; Drosophila; Eyes absent

In eyes absent (eya) mutants, eye progenitor cells undergo cell death early in development. Whereas the phenotype of eya1 is limited to the eye, other mutations are lethal. Genetic and molecular analysis reveals that mutations in one region of the gene cause embryonic lethality, whereas mutations th...