Effective Connectivity in Depression

• Published in: Biological psychiatry : cognitive neuroscience and neuroimaging Vol. 3; no. 2; pp. 187 - 197
• Main Authors: Rolls, Edmund T., Cheng, Wei, Gilson, Matthieu, Qiu, Jiang, Hu, Zicheng, Ruan, Hongtao, Li, Yu, Huang, Chu-Chung, Yang, Albert C., Tsai, Shih-Jen, Zhang, Xiaodong, Zhuang, Kaixiang, Lin, Ching-Po, Deco, Gustavo, Xie, Peng, Feng, Jianfeng
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2018
• Subjects: Cerebral Cortex - physiopathology; Depression; Depressive Disorder, Major - physiopathology; Effective connectivity; Female; Functional connectivity; Hippocampus - physiopathology; Humans; Magnetic Resonance Imaging - methods; Male; Medial temporal lobe; Nerve Net - physiopathology; Neural Pathways - physiopathology; Orbitofrontal cortex; Precuneus; Prefrontal Cortex - physiopathology; Resting-state functional neuroimaging; Reward; Temporal Lobe - physiopathology; Functional connectivity; Orbitofrontal cortex; Precuneus; Depression; Effective connectivity; Medial temporal lobe; Resting-state functional neuroimaging

Resting-state functional connectivity reflects correlations in the activity between brain areas, whereas effective connectivity between different brain areas measures directed influences of brain regions on each other. Using the latter approach, we compare effective connectivity results in patients...