Down syndrome candidate region-1 protein interacts with Tollip and positively modulates interleukin-1 receptor-mediated signaling

• Published in: Biochimica et biophysica acta Vol. 1790; no. 12; pp. 1673 - 1680
• Main Authors: Lee, Jae Youn, Lee, Hyun Jung, Lee, Eun Jung, Jang, Sung Hee, Kim, Hyeyoung, Yoon, Joo-Heon, Chung, Kwang Chul
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2009
• Subjects: Cells, Cultured; Cytokine; Down syndrome; Down Syndrome Critical Region; Humans; IL-1; Inflammation; Interleukin-1 Receptor-Associated Kinases - metabolism; Interleukin-8 - metabolism; Intracellular Signaling Peptides and Proteins - chemistry; Intracellular Signaling Peptides and Proteins - metabolism; Intracellular Signaling Peptides and Proteins - physiology; Models, Biological; Muscle Proteins - chemistry; Muscle Proteins - metabolism; Muscle Proteins - physiology; NF-kappa B - metabolism; Protein Binding; Protein Interaction Domains and Motifs - physiology; Protein Isoforms - metabolism; Protein Isoforms - physiology; Receptors, Interleukin-1 - metabolism; Receptors, Interleukin-1 - physiology; Signal Transduction - physiology; TNF Receptor-Associated Factor 6 - metabolism; Tollip; Up-Regulation; Inflammation; Down syndrome; Down Syndrome Critical Region; IL-1; Cytokine; Tollip

The Down syndrome candidate region-1 gene ( DSCR1, also known as RCAN1) is situated close to the Down Syndrome Critical Region (DSCR), which contains genes responsible for many features of Down syndrome. DSCR1 modulates calcineurin phosphatase activity, though its functional role is incompletely und...