Increased natural killer cell expression of CD16, augmented binding and ADCC activity to rituximab among individuals expressing the FcγRIIIa-158 V/V and V/F polymorphism

• Published in: Blood Vol. 110; no. 7; pp. 2561 - 2564
• Main Authors: Hatjiharissi, Evdoxia, Xu, Lian, Santos, Daniel Ditzel, Hunter, Zachary R., Ciccarelli, Bryan T., Verselis, Sigitas, Modica, Michael, Cao, Yang, Manning, Robert J., Leleu, Xavier, Dimmock, Elizabeth A., Kortsaris, Alexandros, Mitsiades, Constantine, Anderson, Kenneth C., Fox, Edward A., Treon, Steven P.
• Format: Journal Article
• Language: English
• Published: Washington, DC Elsevier Inc 01.10.2007; American Society of Hematology
• Series: Immunobiology

The presence of valine (V) at position 158 of FcγRllla (CD16) is known to improve clinical response to rituximab in indolent non-Hodgkin lymphoma (NHL). Little is known about the basic mechanisms for this observation. We examined natural killer (NK) cells from healthy donors representing the FcγRIII...