Integrin αvβ3 mediates the synergetic regulation of core-binding factor α1 transcriptional activity by gravity and insulin-like growth factor-1 through phosphoinositide 3-kinase signaling - Dai, Zhongquan; Guo, Feima; Wu, Feng; Xu, Hongjie; Yang, Chao; Li, Jinqiao; Liang, Peilong; Zhang, Hongyu; Qu, Lina; Tan, Yingjun; Wan, Yumin; Li, Yinghui (Bone (New York, N.Y.), 2014)
Keywords: 3T3 Cells; Animals; Biological and medical sciences; Blotting, Western; Bone loss; Bone Remodeling - physiology; Cbfa1; Core Binding Factor Alpha 1 Subunit - metabolism; Diseases of the osteoarticular system; Fundamental and applied biological sciences. Psychology; Gravity; Gravity, Altered - adverse effects; IGF-1; Immunoprecipitation; Insulin-Like Growth Factor I - metabolism; Integrin alphaVbeta3 - metabolism; Integrin αvβ3; Medical sciences; Mice; Orthopedics; Osteoporosis. Osteomalacia. Paget disease; Phosphatidylinositol 3-Kinases - metabolism; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Signal Transduction - drug effects; Space Flight; Synergetic regulation; Transfection; Traumas. Diseases due to physical agents; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Weightlessness - adverse effects; CCB; Col1a1; IRS1; ALP; Cbfa1; IGF-1; Synergetic regulation; SMG; EGFP; co-IP; Integrin αvβ3; OSE2; PI3K; Bone loss; HG; Gravity; hypergravity; co-immunoprecipitation; cell culture box; core-binding factor alpha 1; alkaline phosphatase; Type I Collagen alpha 1 chain; Osteoblast-Specific Element 2; insulin receptor substrate 1; enhanced green fluorescent protein; Insulin-like growth factor 1; simulated microgravity; phosphoinositide 3-kinase; Enzyme; Transferases; Diseases of the osteoarticular system; Insulin like growth factor 1; Integrin; Kinase; Morphology; Orthopedics; Osteopenia