Hereditary alpha-tryptasemia in 101 patients with mast cell activation–related symptomatology including anaphylaxis

• Published in: Annals of allergy, asthma, & immunology Vol. 126; no. 6; pp. 655 - 660
• Main Authors: Giannetti, Matthew P., Weller, Emily, Bormans, Concetta, Novak, Peter, Hamilton, Matthew J., Castells, Mariana
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2021

Hereditary alpha-tryptasemia (HαT) is an autosomal dominant genetic trait characterized by multiple copies of the alpha-tryptase gene at the TPSAB1 locus. Previously described symptomatology involves multiple organ systems and anaphylaxis. The spectrum of mast cell activation symptoms is unknown, as...