Indole-3-acetic acid induced cardiogenesis impairment in in-vivo zebrafish via oxidative stress and downregulation of cardiac morphogenic factors

• Published in: Environmental toxicology and pharmacology Vol. 109; p. 104479
• Main Authors: Nayak, S.P. Ramya Ranjan, Boopathi, Seenivasan, Almutairi, Bader O., Arokiyaraj, Selvaraj, Kathiravan, M.K., Arockiaraj, Jesu
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2024
• Subjects: Animals; Apoptosis - drug effects; Cardiogenesis; Cardiotoxic; Down-Regulation - drug effects; Embryo, Nonmammalian - drug effects; Heart - drug effects; Indole acetic acid; Indoleacetic Acids; Lipid Peroxidation - drug effects; Oxidative stress; Oxidative Stress - drug effects; Plant growth regulators; Plant Growth Regulators - toxicity; Teratogenicity; Zebrafish; Zebrafish Proteins - genetics; Zebrafish Proteins - metabolism; Oxidative stress; Indole acetic acid; Plant growth regulators; Cardiogenesis; Cardiotoxic; Teratogenicity

Plant growth regulators (PGRs) are increasingly used to promote sustainable agriculture, but their unregulated use raises concerns about potential environmental risks. Indole-3-acetic acid (IAA), a commonly used PGR, has been the subject of research on its developmental toxicity in the in-vivo zebra...