Indole-3-acetic acid induced cardiogenesis impairment in in-vivo zebrafish via oxidative stress and downregulation of cardiac morphogenic factors
Plant growth regulators (PGRs) are increasingly used to promote sustainable agriculture, but their unregulated use raises concerns about potential environmental risks. Indole-3-acetic acid (IAA), a commonly used PGR, has been the subject of research on its developmental toxicity in the in-vivo zebra...
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| Published in | Environmental toxicology and pharmacology Vol. 109; p. 104479 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
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Elsevier B.V
01.08.2024
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| Abstract | Plant growth regulators (PGRs) are increasingly used to promote sustainable agriculture, but their unregulated use raises concerns about potential environmental risks. Indole-3-acetic acid (IAA), a commonly used PGR, has been the subject of research on its developmental toxicity in the in-vivo zebrafish model. IAA exposure to zebrafish embryos caused oxidative stress, lipid peroxidation, and cellular apoptosis. The study also revealed that critical antioxidant genes including sod, cat, and bcl2 were downregulated, while pro-apoptotic genes such as bax and p53 were upregulated. IAA exposure also hampered normal cardiogenesis by downregulating myl7, amhc, and vmhc genes and potentially influencing zebrafish neurobehavior. The accumulation of IAA was confirmed by HPLC analysis of IAA-exposed zebrafish tissues. These findings underscore the need for further study on the potential ecological consequences of IAA use and the need for sustainable agricultural practices.
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•Indole-3 acetic acid (IAA) induced embryotoxic and teratogenic effect in embryo.•IAA led to an increase in oxidative stress, lipid peroxidation and cellular apoptosis.•Down regulation in antioxidant and up regulation in pro-apoptotic genes due to IAA.•IAA exposure hindered cardiogenesis in developing embryos.•IAA is altering neurobehavior and tissue IAA accumulation in in-vivo larval model. |
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| AbstractList | Plant growth regulators (PGRs) are increasingly used to promote sustainable agriculture, but their unregulated use raises concerns about potential environmental risks. Indole-3-acetic acid (IAA), a commonly used PGR, has been the subject of research on its developmental toxicity in the in-vivo zebrafish model. IAA exposure to zebrafish embryos caused oxidative stress, lipid peroxidation, and cellular apoptosis. The study also revealed that critical antioxidant genes including sod, cat, and bcl2 were downregulated, while pro-apoptotic genes such as bax and p53 were upregulated. IAA exposure also hampered normal cardiogenesis by downregulating myl7, amhc, and vmhc genes and potentially influencing zebrafish neurobehavior. The accumulation of IAA was confirmed by HPLC analysis of IAA-exposed zebrafish tissues. These findings underscore the need for further study on the potential ecological consequences of IAA use and the need for sustainable agricultural practices. Plant growth regulators (PGRs) are increasingly used to promote sustainable agriculture, but their unregulated use raises concerns about potential environmental risks. Indole-3-acetic acid (IAA), a commonly used PGR, has been the subject of research on its developmental toxicity in the in-vivo zebrafish model. IAA exposure to zebrafish embryos caused oxidative stress, lipid peroxidation, and cellular apoptosis. The study also revealed that critical antioxidant genes including sod, cat, and bcl2 were downregulated, while pro-apoptotic genes such as bax and p53 were upregulated. IAA exposure also hampered normal cardiogenesis by downregulating myl7, amhc, and vmhc genes and potentially influencing zebrafish neurobehavior. The accumulation of IAA was confirmed by HPLC analysis of IAA-exposed zebrafish tissues. These findings underscore the need for further study on the potential ecological consequences of IAA use and the need for sustainable agricultural practices. [Display omitted] •Indole-3 acetic acid (IAA) induced embryotoxic and teratogenic effect in embryo.•IAA led to an increase in oxidative stress, lipid peroxidation and cellular apoptosis.•Down regulation in antioxidant and up regulation in pro-apoptotic genes due to IAA.•IAA exposure hindered cardiogenesis in developing embryos.•IAA is altering neurobehavior and tissue IAA accumulation in in-vivo larval model. Plant growth regulators (PGRs) are increasingly used to promote sustainable agriculture, but their unregulated use raises concerns about potential environmental risks. Indole-3-acetic acid (IAA), a commonly used PGR, has been the subject of research on its developmental toxicity in the in-vivo zebrafish model. IAA exposure to zebrafish embryos caused oxidative stress, lipid peroxidation, and cellular apoptosis. The study also revealed that critical antioxidant genes including sod, cat, and bcl2 were downregulated, while pro-apoptotic genes such as bax and p53 were upregulated. IAA exposure also hampered normal cardiogenesis by downregulating myl7, amhc, and vmhc genes and potentially influencing zebrafish neurobehavior. The accumulation of IAA was confirmed by HPLC analysis of IAA-exposed zebrafish tissues. These findings underscore the need for further study on the potential ecological consequences of IAA use and the need for sustainable agricultural practices.Plant growth regulators (PGRs) are increasingly used to promote sustainable agriculture, but their unregulated use raises concerns about potential environmental risks. Indole-3-acetic acid (IAA), a commonly used PGR, has been the subject of research on its developmental toxicity in the in-vivo zebrafish model. IAA exposure to zebrafish embryos caused oxidative stress, lipid peroxidation, and cellular apoptosis. The study also revealed that critical antioxidant genes including sod, cat, and bcl2 were downregulated, while pro-apoptotic genes such as bax and p53 were upregulated. IAA exposure also hampered normal cardiogenesis by downregulating myl7, amhc, and vmhc genes and potentially influencing zebrafish neurobehavior. The accumulation of IAA was confirmed by HPLC analysis of IAA-exposed zebrafish tissues. These findings underscore the need for further study on the potential ecological consequences of IAA use and the need for sustainable agricultural practices. |
| ArticleNumber | 104479 |
| Author | Arokiyaraj, Selvaraj Kathiravan, M.K. Boopathi, Seenivasan Almutairi, Bader O. Nayak, S.P. Ramya Ranjan Arockiaraj, Jesu |
| Author_xml | – sequence: 1 givenname: S.P. Ramya Ranjan surname: Nayak fullname: Nayak, S.P. Ramya Ranjan organization: Toxicology and Pharmacology Laboratory, Department of Biotechnology, Faculty of Science and Humanities, SRM Institute of Science and Technology, Chengalpattu District, Kattankulathur, 603203, Tamil Nadu, India – sequence: 2 givenname: Seenivasan surname: Boopathi fullname: Boopathi, Seenivasan organization: Toxicology and Pharmacology Laboratory, Department of Biotechnology, Faculty of Science and Humanities, SRM Institute of Science and Technology, Chengalpattu District, Kattankulathur, 603203, Tamil Nadu, India – sequence: 3 givenname: Bader O. surname: Almutairi fullname: Almutairi, Bader O. organization: Department of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia – sequence: 4 givenname: Selvaraj surname: Arokiyaraj fullname: Arokiyaraj, Selvaraj organization: Department of Food Science & Biotechnology, Sejong University, Seoul 05006, South Korea – sequence: 5 givenname: M.K. surname: Kathiravan fullname: Kathiravan, M.K. organization: Dr APJ Abdul Kalam Research Lab, Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM Institute of Science and Technology, Chengalpattu District, Kattankulathur 603203, Tamil Nadu, India – sequence: 6 givenname: Jesu orcidid: 0000-0002-0240-7141 surname: Arockiaraj fullname: Arockiaraj, Jesu email: jesuaroa@srmist.edu.in organization: Toxicology and Pharmacology Laboratory, Department of Biotechnology, Faculty of Science and Humanities, SRM Institute of Science and Technology, Chengalpattu District, Kattankulathur, 603203, Tamil Nadu, India |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38821154$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_foodcont_2025_111155 crossref_primary_10_1080_15376516_2025_2473525 crossref_primary_10_1016_j_aquaculture_2025_742389 crossref_primary_10_1016_j_jnutbio_2025_109887 |
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| Keywords | Oxidative stress Indole acetic acid Plant growth regulators Cardiogenesis Cardiotoxic Teratogenicity |
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| SubjectTerms | Animals Apoptosis - drug effects Cardiogenesis Cardiotoxic Down-Regulation - drug effects Embryo, Nonmammalian - drug effects Heart - drug effects Indole acetic acid Indoleacetic Acids Lipid Peroxidation - drug effects Oxidative stress Oxidative Stress - drug effects Plant growth regulators Plant Growth Regulators - toxicity Teratogenicity Zebrafish Zebrafish Proteins - genetics Zebrafish Proteins - metabolism |
| Title | Indole-3-acetic acid induced cardiogenesis impairment in in-vivo zebrafish via oxidative stress and downregulation of cardiac morphogenic factors |
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