5-Hydroxymethylcytosines in circulating cell-free DNA as a diagnostic biomarker for nasopharyngeal carcinoma

• Published in: European journal of cancer (1990) Vol. 210; p. 114294
• Main Authors: Chen, Bijuan, Wang, Di, Xu, Yun, Guo, Qiaojuan, Pan, Jianji, Yu, Sisi, Fang, Yunxiang, Xiao, Shuxiang, Ruan, Yuanyuan, Yang, Shanshan, Lin, Mingan, Hong, Jinsheng, Zhan, Zhouwei, Lin, Shaojun
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2024
• Subjects: 5-hydroxymethylcytosine; 5-Methylcytosine - analogs & derivatives; 5-Methylcytosine - blood; Adult; Aged; Biomarkers, Tumor - blood; Biomarkers, Tumor - genetics; Cell-Free Nucleic Acids - blood; cfDNA; Diagnosis; Epigenetics; Female; Humans; Male; Middle Aged; Nasopharyngeal carcinoma; Nasopharyngeal Carcinoma - blood; Nasopharyngeal Carcinoma - diagnosis; Nasopharyngeal Carcinoma - genetics; Nasopharyngeal Neoplasms - blood; Nasopharyngeal Neoplasms - diagnosis; Nasopharyngeal Neoplasms - genetics; ROC Curve; Nasopharyngeal carcinoma; Epigenetics; Diagnosis; cfDNA; 5-hydroxymethylcytosine

To evaluate the diagnostic value of 5-hydroxymethylcytosines (5hmC) in circulating cell-free DNA (cfDNA) for nasopharyngeal carcinoma (NPC) and to develop a diagnostic model. Genome-wide 5hmC profiles in cfDNA from 174 NPC patients and 146 non-cancer individuals were analyzed using the 5hmC-Seal tec...