Treatment of painful temporomandibular joints with a cyclooxygenase-2 inhibitor: a randomized placebo-controlled comparison of celecoxib to naproxen

• Published in: Pain (Amsterdam) Vol. 111; no. 1; pp. 13 - 21
• Main Authors: Ta, Lauren E., Dionne, Raymond A.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.09.2004; Elsevier
• Subjects: Adult; Analgesics; Biological and medical sciences; Celecoxib; Chronic Disease; Chronic pain; Clinical trial; Coxibs; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors - administration & dosage; Cyclooxygenase Inhibitors - adverse effects; Facial bones, jaws, teeth, parodontium: diseases, semeiology; Facial Pain - drug therapy; Facial Pain - etiology; Female; Humans; Isoenzymes - antagonists & inhibitors; Male; Medical sciences; Membrane Proteins; Middle Aged; Naproxen - administration & dosage; Naproxen - adverse effects; Neuropharmacology; Non tumoral diseases; Non-steroidal anti-inflammatory drug; Otorhinolaryngology. Stomatology; Pharmacology. Drug treatments; Placebos; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Quality of Life; Range of Motion, Articular; Sulfonamides - administration & dosage; Sulfonamides - adverse effects; Temporomandibular disorder; Temporomandibular Joint Disorders - complications; Treatment Outcome; Clinical trial; Temporomandibular disorder; Non-steroidal anti-inflammatory drug; Chronic pain; Coxibs; Cyclooxygenase 2; Visual analogue scale; Diseases of the osteoarticular system; Temporomandibular joint; Temporomandibular joint dysfunction; Osteoarticular system; Improvement; Pain; Naproxen; Maxillary disease; Human; Enzyme; Stomatology; Evaluation scale; Enzyme inhibitor; Celecoxib; Quality of life; Non steroidal antiinflammatory agent; Analgesia; Analgesic; Treatment; Arthropathy; Oxidoreductases

To compare the efficacy and adverse effects of celecoxib, a cyclooxygenase-2 (COX-2) inhibitor, with naproxen, a non-steroidal anti-inflammatory drug, and placebo in the treatment of painful temporomandibular joints (TMJs). In this randomized, double-blind, placebo-controlled trial, 68 subjects with...