A phase 2 study of oral difelikefalin in subjects with chronic kidney disease and moderate-to-severe pruritus - Yosipovitch, Gil; Awad, Ahmed; Spencer, Robert H.; Munera, Catherine; Menzaghi, Frédérique (Journal of the American Academy of Dermatology, 2023)
Keywords: chronic kidney disease; chronic kidney disease associated pruritus; CR845; difelikefalin; Double-Blind Method; end-stage renal disease; Humans; itch; kappa opioid receptor agonist; Kidney Failure, Chronic; Piperidines - therapeutic use; pruritus; Pruritus - drug therapy; Pruritus - etiology; quality of life; Renal Dialysis - adverse effects; Severity of Illness Index; uremic pruritus; pruritus; PGI-C; itch; chronic kidney disease; uremic pruritus; difelikefalin; end-stage renal disease; kappa opioid receptor agonist; TEAE; chronic kidney disease associated pruritus; WI-NRS; CR845; quality of life; HD; CKD; NDD-CKD