The Anti-proliferative Effects of Recombinant Human Lysozyme on Human Gastric Cancer Cells

• Published in: Journal of international medical research Vol. 35; no. 3; pp. 353 - 360
• Main Authors: Guo, TK, Zhao, XH, Xie, XD, Chen, ZH, Zhou, CS, Wei, LL, Zhang, H
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.05.2007
• Subjects: Antineoplastic Agents - pharmacology; Cell Proliferation; Cells, Cultured; Cloning, Molecular; Drug Screening Assays, Antitumor; Fibroblasts - drug effects; Humans; Lung - cytology; Muramidase - genetics; Muramidase - pharmacology; Muramidase - toxicity; Recombinant Proteins - genetics; Recombinant Proteins - pharmacology; Recombinant Proteins - toxicity; Stomach Neoplasms - drug therapy; Stomach Neoplasms - pathology; Toxicity Tests; Tumor Cells, Cultured; Recombinant human lysozyme; Anti-cancer agent; Human lung fibroblasts; Human gastric cancer cell lines

We investigated the anti-proliferative effects of recombinant human lysozyme (rHlys) on gastric cancer cell lines and normal human lung fibroblasts. Using conventional molecular cloning techniques we purified rHlys, which we incubated with cultured cells and measured the effects on cell proliferatio...