Development-Dependent Changes in the NR2 Subtype of the N-Methyl-D-Aspartate Receptor in the Suprachiasmatic Nucleus of the Rat

• Published in: Journal of biological rhythms Vol. 34; no. 1; p. 39
• Main Authors: Herrera-Zamora, J Manuel, Castro-Sánchez, Luis A, Reyes-Mendez, Miriam, Aguilar-Martinez, Irving, Osuna-López, Fernando, Moreno-Galindo, Eloy G, Navarro-Polanco, Ricardo A, Aguilar-Roblero, Raul A, Sánchez-Pastor, Enrique, Alamilla, Javier
• Format: Journal Article
• Language: English
• Published: United States 01.02.2019
• Subjects: Aging; Animals; Brain - physiology; Circadian Rhythm; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors; Receptors, N-Methyl-D-Aspartate - physiology; Suprachiasmatic Nucleus Neurons - physiology; Synapses - physiology; NMDA; development; retinohypothalamic tract; glutamate; NR2; SCN

The suprachiasmatic nucleus (SCN) is the main brain clock that regulates circadian rhythms in mammals. The SCN synchronizes to the LD cycle through the retinohypothalamic tract (RHT), which projects to ventral SCN neurons via glutamatergic synapses. Released glutamate activates N-methyl-D-aspartate...