Amygdala Activation and Connectivity to Emotional Processing Distinguishes Asymptomatic Patients With Bipolar Disorders and Unipolar Depression

• Published in: Biological psychiatry : cognitive neuroscience and neuroimaging Vol. 4; no. 4; pp. 361 - 370
• Main Authors: Korgaonkar, Mayuresh S., Erlinger, May, Breukelaar, Isabella A., Boyce, Philip, Hazell, Philip, Antees, Cassandra, Foster, Sheryl, Grieve, Stuart M., Gomes, Lavier, Williams, Leanne M., Harris, Anthony W.F., Malhi, Gin S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2019
• Subjects: Adolescent; Adult; Amygdala; Amygdala - diagnostic imaging; Amygdala - physiopathology; Bipolar Disorder - diagnostic imaging; Bipolar Disorder - physiopathology; Bipolar disorders; Cerebral Cortex - diagnostic imaging; Cerebral Cortex - physiopathology; Connectome; Depression; Depressive Disorder, Major - diagnostic imaging; Depressive Disorder, Major - physiopathology; Emotion processing; Emotions - physiology; Facial Expression; Facial Recognition - physiology; Female; fMRI connectivity; Hippocampus - diagnostic imaging; Hippocampus - physiopathology; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Remission; Remission Induction; Social Perception; Subliminal Stimulation; Young Adult; fMRI connectivity; Depression; Remission; Amygdala; Emotion processing; Bipolar disorders

Mechanistically based neural markers, such as amygdala reactivity, offer one approach to addressing the challenges of differentiating bipolar and unipolar depressive disorders independently from mood state and acute symptoms. Although emotion-elicited amygdala reactivity has been found to distinguis...