RAC1 activation mediates Twist1-induced cancer cell migration

• Published in: Nature cell biology Vol. 14; no. 4; pp. 366 - 374
• Main Authors: Yang, Wen-Hao, Lan, Hsin-Yi, Huang, Chi-Hung, Tai, Shyh-Kuan, Tzeng, Cheng-Hwai, Kao, Shou-Yen, Wu, Kou-Juey, Hung, Mien-Chie, Yang, Muh-Hwa
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.04.2012; Nature Publishing Group
• Subjects: 631/337/384/331; 631/67/322; 631/80/84/2176; Adhesion; Aggregates; Biology; Biomedical and Life Sciences; Cancer Research; Cell adhesion & migration; Cell Biology; Cell Line, Tumor; Cell Movement; Clinical medicine; Developmental Biology; Head & neck cancer; HEK293 Cells; Humans; Invasiveness; Life Sciences; Medicine; Metastasis; MicroRNAs; Motility; Neoplasms - metabolism; Neoplasms - pathology; Nuclear Proteins - metabolism; Oncology; rac1 GTP-Binding Protein - metabolism; Stem Cells; Twist-Related Protein 1 - metabolism; Taiwan

Epithelial–mesenchymal transition (EMT), which is characterized by the suppression of the adhesion protein E-cadherin, is a crucial process that promotes metastasis and stem-like properties of cancer cells. However, the dissociation of cellular aggregates is not sufficient to explain why cancer cell...