Effect of Topical Propranolol Gel on Plasma Renin,Angiotensin Ⅱ and Vascular Endothelial Growth Factor in Superficial Infantile Hemangiomas

• Published in: Journal of Huazhong University of Science and Technology. Medical sciences Vol. 35; no. 5; pp. 759 - 762
• Main Author: 唐玉娟 张再重 陈少全 陈淑明 黎成金 陈剑伟 原博 夏印 王烈
• Format: Journal Article
• Language: English
• Published: Wuhan Huazhong University of Science and Technology 01.10.2015; Department of General Surgery, Fuzhou General Hospital of Nanjing Command of PLA, Fuzhou 350025, China; Department of General Surgery, Dongfang Hospital, Xiamen University, Fuzhou 350025, China; Department of General Surgery, Fuzhou Clinic Medical College, Fujian Medical University, Fuzhou 350025, China; Department of Vascular Surgery, Hubei Provincial Hospital of TCM, Wuhan 430000, China%Department of General Surgery, Fuzhou General Hospital of Nanjing Command of PLA, Fuzhou 350025, China
• Subjects: Administration, Cutaneous; Adrenergic beta-Antagonists - therapeutic use; Angiotensin II - blood; Case-Control Studies; Female; Gels; Hemangioma, Capillary - blood; Hemangioma, Capillary - blood supply; Hemangioma, Capillary - drug therapy; Hemangioma, Capillary - pathology; Humans; Infant; Infant, Newborn; Male; Medicine; Medicine & Public Health; Propranolol - therapeutic use; Renin - blood; Skin Neoplasms - blood; Skin Neoplasms - blood supply; Skin Neoplasms - drug therapy; Skin Neoplasms - pathology; Treatment Outcome; Vascular Endothelial Growth Factor A - blood; VEGF; 凝胶剂; 外用; 普萘洛尔; 肾素; 血浆; 血管内皮生长因子; 血管紧张素; propranolol gel; infantile hemangiomas; angiotensin II; renin; vascular endothelial growth factor; angiotensin
• ISSN: 1672-0733; 1993-1352
• DOI: 10.1007/s11596-015-1503-5

The effect of topical propranolol gel on the levels of plasma renin,angiotensin Ⅱ（ATⅡ） and vascular endothelial growth factor（VEGF） in superficial infantile hemangiomas（IHs） was investigated. Thirty-three consecutive children with superficial IHs were observed pre-treatment,1 and 3 months after application of topical propranolol gel for the levels of plasma renin,AT Ⅱand VEGF in Department of General Surgery of Dongfang Hospital from February 2013 to February 2014. The plasma results of IHs were compared with those of 30 healthy infants of the same age from out-patient department. The clinical efficiency of topical propranolol gel at 1st,and 3rd month after application was 45%,and 82% respectively. The levels of plasma renin,AT and VEGF in patients preⅡ-treatment were higher than those in healthy infants（565.86±49.66 vs. 18.19±3.56,3.20±0.39 vs 0.30±0.03,and 362.16±27.29 vs. 85.63±8.14,P〈0.05）. The concentrations of VEGF and renin at 1st and 3rd month after treatment were decreased obviously as compared with those pre-treatment（271.51±18.59 vs. 362.16±27.29,and 405.18±42.52 vs. 565.86±49.66 P〈0.05; 240.80±19.89 vs. 362.16±27.29,and 325.90±35.78 vs. 565.86±49.66,P〈0.05,respectively）,but the levels of plasma AT declined slightly Ⅱ（2.96±0.37 vs. 3.20±0.39,and 2.47±0.27 vs. 3.20±0.39,P〉0.05）. It was indicated that the increased renin,AT Ⅱand VEGF might play a role in the onset or development of IHs. Propranolol gel may suppress the proliferation of IHs by reducing VEGF.