High urinary excretion of glycosaminoglycans: a possible marker of glomerular involvement in diabetes

• Published in: Metabolism, clinical and experimental Vol. 38; no. 5; p. 419
• Main Authors: Gambaro, G, Cicerello, E, Mastrosimone, S, Lavagnini, T, Baggio, B
• Format: Journal Article
• Language: English
• Published: United States 01.05.1989
• Subjects: Adult; Albuminuria; Biomarkers - urine; DIABETE; DIABETES; Diabetes Mellitus, Type 1 - metabolism; Diabetes Mellitus, Type 1 - urine; EXCRECION; EXCRETION; Female; FILTRACION; FILTRATION; Glycosaminoglycans - urine; Humans; Kidney Glomerulus - metabolism; Lysine; Male; Middle Aged; ORINA; POLISACARIDOS; POLYHOLOSIDE; POLYSACCHARIDES; URINE

Many insulin-dependent diabetic patients with albuminuria in the "not at risk range" for diabetic nephropathy present high urinary excretion rates of glycosaminoglycans. A lysine provocative test in these subjects disclosed abnormal urinary excretion of albumin, unlike findings obtained in...