High urinary excretion of glycosaminoglycans: a possible marker of glomerular involvement in diabetes

Many insulin-dependent diabetic patients with albuminuria in the "not at risk range" for diabetic nephropathy present high urinary excretion rates of glycosaminoglycans. A lysine provocative test in these subjects disclosed abnormal urinary excretion of albumin, unlike findings obtained in...

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Bibliographic Details
Published inMetabolism, clinical and experimental Vol. 38; no. 5; p. 419
Main Authors Gambaro, G, Cicerello, E, Mastrosimone, S, Lavagnini, T, Baggio, B
Format Journal Article
LanguageEnglish
Published United States 01.05.1989
Subjects
Adult
Albuminuria
Biomarkers - urine
DIABETE
DIABETES
Diabetes Mellitus, Type 1 - metabolism
Diabetes Mellitus, Type 1 - urine
EXCRECION
EXCRETION
Female
FILTRACION
FILTRATION
Glycosaminoglycans - urine
Humans
Kidney Glomerulus - metabolism
Lysine
Male
Middle Aged
ORINA
POLISACARIDOS
POLYHOLOSIDE
POLYSACCHARIDES
URINE
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Summary:Many insulin-dependent diabetic patients with albuminuria in the "not at risk range" for diabetic nephropathy present high urinary excretion rates of glycosaminoglycans. A lysine provocative test in these subjects disclosed abnormal urinary excretion of albumin, unlike findings obtained in insulin-dependent diabetic patients with normal urinary excretion rates of glycosaminoglycans. These data support the hypothesis that high urinary excretion of glycosaminoglycans is a marker of glomerular involvement in diabetes mellitus.
Bibliography:S30
8916742
ISSN:0026-0495
1532-8600
DOI:10.1016/0026-0495(89)90190-X