Balance of Gata3 and Ramp2 in hepatocytes regulates hepatic vascular reconstitution in postoperative liver regeneration

• Published in: Journal of hepatology Vol. 80; no. 2; pp. 309 - 321
• Main Authors: Wang, Bibo, Shen, Hao, Wei, Yating, Liu, Fuchen, Yang, Yuan, Yu, Han, Fu, Jing, Cui, Xiuliang, Yu, Ting, Xu, Ying, Liu, Yitian, Dong, Hui, Shen, Feng, Zhou, Weiping, Liu, Hui, Chen, Yao, Wang, Hongyang
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2024
• Subjects: ALPPS; Animals; Endothelial Cells; GATA3 Transcription Factor; Hepatectomy - adverse effects; Hepatocytes - physiology; hepatovascular reconstruction; Humans; Ligation; Liver - surgery; liver failure; Liver Failure - etiology; Liver Neoplasms; liver regeneration; Liver Regeneration - physiology; Mice; PEDF; Portal Vein - surgery; Receptor Activity-Modifying Protein 2; Retrospective Studies; Vascular Endothelial Growth Factor A; VEGFA; liver failure; PEDF; liver regeneration; ALPPS; hepatovascular reconstruction; VEGFA

Post-hepatectomy liver failure (PHLF) leads to poor prognosis in patients undergoing hepatectomy, with hepatic vascular reconstitution playing a critical role. However, the regulators of hepatic vascular reconstitution remain unclear. In this study, we aimed to investigate the regulatory mechanisms...