Epigenetic modifications in the nervous system and their impact upon cognitive impairments

• Published in: Neuropharmacology Vol. 80; pp. 70 - 82
• Main Authors: Rudenko, Andrii, Tsai, Li-Huei
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.05.2014
• Subjects: 5-Methylcytosine - analogs & derivatives; Acetylation; Animals; Central nervous system; Central Nervous System - enzymology; Central Nervous System - metabolism; Cognition; Cognition Disorders - enzymology; Cognition Disorders - etiology; Cognition Disorders - metabolism; Cognitive disorders; Cytosine - analogs & derivatives; Cytosine - metabolism; DNA Methylation; DNA methylation and hydroxymethylation; Epigenesis, Genetic; Epigenetics; Gene Expression Regulation; Histone acetylation; Histone Deacetylases - genetics; Histone Deacetylases - metabolism; Histones - metabolism; Humans; Learning; Learning and memory; Memory; Models, Biological; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Neurons - enzymology; Neurons - metabolism; Protein Processing, Post-Translational; Rett Syndrome - enzymology; Rett Syndrome - metabolism; Rett Syndrome - physiopathology; Rubinstein-Taybi Syndrome - enzymology; Rubinstein-Taybi Syndrome - metabolism; Rubinstein-Taybi Syndrome - physiopathology; Learning and memory; Epigenetics; DNA methylation and hydroxymethylation; Cognitive disorders; Histone acetylation; Central nervous system

Epigenetic regulation has been long considered to be a critical mechanism in the control of key aspects of cellular functions such as cell division, growth, and cell fate determination. Exciting recent developments have demonstrated that epigenetic mechanisms can also play necessary roles in the ner...