Hypoxia accelerates intraplaque neovascularization derived from endothelial progenitor cells in carotid stenosis

• Published in: Journal of neurosurgery Vol. 131; no. 3; p. 884
• Main Authors: Kashiwazaki, Daina, Koh, Masaki, Uchino, Haruto, Akioka, Naoki, Kuwayama, Naoya, Noguchi, Kyo, Kuroda, Satoshi
• Format: Journal Article
• Language: English
• Published: United States 01.09.2019
• Subjects: Aged; Aged, 80 and over; Antigens, CD - metabolism; Carotid Stenosis - etiology; Carotid Stenosis - metabolism; Carotid Stenosis - pathology; Endarterectomy, Carotid; Endothelial Progenitor Cells - physiology; Female; Humans; Hypoxia - complications; Hypoxia - metabolism; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Male; Neovascularization, Pathologic - complications; Neovascularization, Pathologic - metabolism; Plaque, Atherosclerotic - etiology; Plaque, Atherosclerotic - metabolism; Plaque, Atherosclerotic - pathology; Vascular Endothelial Growth Factor Receptor-2 - metabolism; VEGF = vascular endothelial growth factor; hypoxia; plaque; AB = diaminobenzidine tetrahydrochloride; endothelial progenitor cell; IPH = intraplaque hemorrhage; vulnerability; EPC = endothelial progenitor cell; vascular disorders; HIF = hypoxia-inducible factor; carotid stenosis; TOF = time of flight; VEGFR = VEGF receptor

The relationship between intraplaque hypoxia and intraplaque hemorrhage (IPH) has been reported, but the details remain obscure. In this study, the authors aimed to clarify the relationship among intraplaque hypoxia, endothelial progenitor cells (EPCs), and neovascularization, which causes IPH. The...