Endogenous tumor necrosis factor inhibits the cytotoxicity of exogenous tumor necrosis factor and adriamycin in pancreatic carcinoma cells

• Published in: Pancreas Vol. 13; no. 4; p. 395
• Main Authors: Watanabe, N, Tsuji, N, Tsuji, Y, Sasaki, H, Okamoto, T, Akiyama, S, Kobayashi, D, Sato, T, Yamauchi, N, Niitsu, Y
• Format: Journal Article
• Language: English
• Published: United States 01.11.1996
• Subjects: Doxorubicin - therapeutic use; Drug Resistance, Neoplasm; Gene Expression; Humans; Pancreatic Neoplasms - drug therapy; Pancreatic Neoplasms - enzymology; Superoxide Dismutase - metabolism; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha - genetics; Tumor Necrosis Factor-alpha - pharmacology; Tumor Necrosis Factor-alpha - therapeutic use

Pancreatic carcinoma is one of the most devastating neoplasms with regard to its resistance to conventional therapy. In a previous report, we found that endogenous tumor necrosis factor (enTNF) exerts an intracellular protective effect against exogenous TNF- and Adriamycin (ADM)-induced cytotoxicity...