Abnormalities in 3-Dimensional Left Ventricular Mechanics With Anthracycline Chemotherapy Are Associated With Systolic and Diastolic Dysfunction

• Published in: JACC. Cardiovascular imaging Vol. 11; no. 8; pp. 1059 - 1068
• Main Authors: Zhang, Kathleen W., Finkelman, Brian S., Gulati, Gaurav, Narayan, Hari K., Upshaw, Jenica, Narayan, Vivek, Plappert, Ted, Englefield, Virginia, Smith, Amanda M., Zhang, Carina, Hundley, W. Gregory, Ky, Bonnie
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2018
• Subjects: 3D echocardiography; Adult; anthracyclines; Antibiotics, Antineoplastic - adverse effects; Biomechanical Phenomena; Breast Neoplasms - drug therapy; cardio-oncology; Diastole; Doxorubicin - adverse effects; Echocardiography, Doppler; Echocardiography, Three-Dimensional; Female; Humans; Longitudinal Studies; Middle Aged; Predictive Value of Tests; Prospective Studies; Risk Factors; Stroke Volume; Systole; Time Factors; Ventricular Dysfunction, Left - chemically induced; Ventricular Dysfunction, Left - diagnostic imaging; Ventricular Dysfunction, Left - physiopathology; Ventricular Function, Left - drug effects; STE; GCS; LVEF; anthracyclines; cardio-oncology; 3D echocardiography; IQR; GLS

The objective of this study was to evaluate the changes in three-dimensional (3D) speckle-tracking echocardiography–derived measures of mechanics and their associations with systolic and diastolic dysfunction after anthracyclines. An improved understanding of the changes in 3D cardiac mechanics with...