Danshen Modulates Nrf2-mediated Signaling Pathway in Cisplatin-induced Renal Injury

• Published in: Current medical science Vol. 37; no. 5; pp. 761 - 765
• Main Author: 曹思思;颜苗;侯振彦;陈莹;蒋云生;樊新荣;方平飞;张毕奎
• Format: Journal Article
• Language: English
• Published: Wuhan Huazhong University of Science and Technology 01.10.2017; Department of Pharmacy, the Second Xiangya Hospital Central South University, Changsha 410011, China; School of Pharmaceutical Sciences, Central South University, Changsha 410013, China%Department of Pharmacy, the Second Xiangya Hospital Central South University, Changsha 410011, China%Department of Nephrology, the Second Xiangya Hospital Central South University, Changsha 410011, China%Institute of Basic Theories of Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China
• Subjects: Medicine; Medicine & Public Health; nephrotoxicity; cisplatin; Nrf2; Danshen; oxidative stress

Danshen, an efficacious agent for cardiovascular diseases, has been found to play an essential role in kidney injury. In the present study, the effect of Danshen on cisplatin-induced renal dysfunction was investigated in a mouse model. Danshen was administered to mice at a dose of 3 g/kg 4 days befo...