Risk Factors for Mortality in 220 Patients With COVID-19 in Wuhan, China: A Single-Center, Retrospective Study

• Published in: Ear, nose, & throat journal Vol. 100; no. 2_suppl; pp. 140S - 147S
• Main Authors: Zhou, Shuliang, Mi, Sulin, Luo, Shuilian, Wang, Ying, Ren, Bin, Cai, Lin, Wu, Meng
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.04.2021; SAGE PUBLICATIONS, INC
• Subjects: Acute Kidney Injury - etiology; Acute Kidney Injury - physiopathology; Acute Kidney Injury - therapy; Adult; Age; Age Factors; Aged; Anti-Bacterial Agents - therapeutic use; Antiviral Agents - therapeutic use; Arrhythmias, Cardiac - etiology; Arrhythmias, Cardiac - physiopathology; Arrhythmias, Cardiac - therapy; Case-Control Studies; China; Comorbidity; Coronaviruses; COVID-19; COVID-19 - complications; COVID-19 - mortality; COVID-19 - physiopathology; COVID-19 - therapy; Female; Glucocorticoids - therapeutic use; Humans; Laboratories; Liver Diseases - etiology; Liver Diseases - physiopathology; Liver Diseases - therapy; Logistic Models; Male; Middle Aged; Mortality; Multivariate Analysis; Organ Dysfunction Scores; Oxygen Inhalation Therapy; Prognosis; Respiration, Artificial; Respiratory Distress Syndrome - etiology; Respiratory Distress Syndrome - physiopathology; Respiratory Distress Syndrome - therapy; Respiratory Rate; Retrospective Studies; Risk Factors; SARS-CoV-2; Sepsis - etiology; Sepsis - physiopathology; Sepsis - therapy; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; China; COVID-19; SARS-CoV-2; risk factors for mortality; Wuhan
• ISSN: 0145-5613; 1942-7522
• DOI: 10.1177/0145561320972608

Background: An outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 infection occurred in Wuhan, China, in December 2019. To date, the analysis of fatal cases and the risk factors for death have rarely been reported. Methods: In this study, 220 adult patients with confirmed and suspected COVID-19 were enrolled. Clinical characteristics, laboratory data, treatments, and complications were compared between 168 survivors and 52 nonsurvivors. Univariable analysis and multivariable logistic regression were used to investigate the risk factors for mortality. Results: A total of 220 patients (168 were discharged and 52 died in the hospital) were enrolled in the study. The median age of all patients was 59.5 (47.0-69.0) years, and the median age of patients who died was significantly older than that of patients who survived (70.5 vs 56.0 years, respectively; P < .001). According to multivariate logistic regression, older age (odds ratio: 1.09, 95% CI: 1.03-1.15; P = .001), initial Sequential Organ Failure Assessment (SOFA) score >2 (37.4, 9.4-148.0; P = .011), and respiratory rate >24 per minute (10.89, 1.47-80.67; P = .019) were independent risk factors for mortality. Conclusion: Clinical and laboratory parameters predicting poor prognosis including older age, baseline SOFA score >2, and respiratory rate >24 per minute were identified.