Long non-coding RNA H19 mediates mechanical tension-induced osteogenesis of bone marrow mesenchymal stem cells via FAK by sponging miR-138

• Published in: Bone (New York, N.Y.) Vol. 108; pp. 62 - 70
• Main Authors: Wu, Jiajing, Zhao, Jing, Sun, Lian, Pan, Yongchu, Wang, Hua, Zhang, Wei-Bing
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2018
• Subjects: Base Sequence; Bone marrow mesenchymal stem cells (BMMSCs); Cell Differentiation - genetics; Cell Line; Focal Adhesion Protein-Tyrosine Kinases - metabolism; Humans; LncRNA H19; Mechanical tension; Mesenchymal Stem Cells - metabolism; MicroRNAs - genetics; MicroRNAs - metabolism; miR-138; Osteogenesis; Osteogenesis - genetics; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism; Stress, Mechanical; Bone marrow mesenchymal stem cells (BMMSCs); LncRNA H19; miR-138; Osteogenesis; Mechanical tension

Bone marrow mesenchymal stem cells (BMMSCs) provide the biological basis for bone reconstruction. Mechanical tension stimulation as a potent modulator is able to promote osteogenic capability of BMMSCs. Long non-coding RNAs (LncRNAs) as competing endogenous RNAs (ceRNAs) for microRNAs, are postulate...