CCL18 differentiates dendritic cells in tolerogenic cells able to prime regulatory T cells in healthy subjects

• Published in: Blood Vol. 118; no. 13; pp. 3549 - 3558
• Main Authors: Azzaoui, Imane, Yahia, Saliha Ait, Chang, Ying, Vorng, Han, Morales, Olivier, Fan, Ying, Delhem, Nadira, Ple, Coline, Tonnel, André-Bernard, Wallaert, Benoit, Tsicopoulos, Anne
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 29.09.2011
• Subjects: Antigen Presentation - drug effects; Antigen Presentation - immunology; CD4-Positive T-Lymphocytes - drug effects; CD4-Positive T-Lymphocytes - immunology; CD4-Positive T-Lymphocytes - metabolism; CD4-Positive T-Lymphocytes - physiology; Cell Differentiation - drug effects; Cell Differentiation - genetics; Cells, Cultured; Chemokines, CC - genetics; Chemokines, CC - metabolism; Chemokines, CC - pharmacology; Chemokines, CC - physiology; Dendritic Cells - drug effects; Dendritic Cells - immunology; Dendritic Cells - metabolism; Dendritic Cells - physiology; Forkhead Transcription Factors - metabolism; Health; Humans; Hypersensitivity - immunology; Hypersensitivity - metabolism; Immune Tolerance - drug effects; Immune Tolerance - genetics; Immune Tolerance - immunology; Interleukin-10 - metabolism; Primary Cell Culture; T-Lymphocytes, Regulatory - drug effects; T-Lymphocytes, Regulatory - immunology; T-Lymphocytes, Regulatory - metabolism

The aim of this study was to evaluate the nonchemotactic function of CCL18 on human dendritic cells (DCs). In different protocols of DC differentiation, CCL18 was highly produced, suggesting that it may constitute a mandatory mediator of the differentiation process. Differentiation of monocytes from...