ATPase family AAA domain-containing 3A is a novel anti-apoptotic factor in lung adenocarcinoma cells
AAA domain-containing 3A (ATAD3A) is a member of the AAA-ATPase family. Three forms of ATAD3 have been identified: ATAD3A, ATAD3B and ATAD3C. In this study, we examined the type and expression of ATAD3 in lung adenocarcinoma (LADC). Expression of ATAD3A was detected by reverse transcription-polymera...
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| Published in | Journal of cell science Vol. 123; no. 7; pp. 1171 - 1180 |
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| Main Authors | , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
The Company of Biologists Limited
01.04.2010
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| Online Access | Get full text |
| ISSN | 0021-9533 1477-9137 1477-9137 |
| DOI | 10.1242/jcs.062034 |
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| Abstract | AAA domain-containing 3A (ATAD3A) is a member of the AAA-ATPase family. Three forms of ATAD3 have been identified: ATAD3A, ATAD3B and ATAD3C. In this study, we examined the type and expression of ATAD3 in lung adenocarcinoma (LADC). Expression of ATAD3A was detected by reverse transcription-polymerase chain reaction, immunoblotting, immunohistochemistry and confocal immunofluorescent microscopy. Our results show that ATAD3A is the major form expressed in LADC. Silencing of ATAD3A expression increased mitochondrial fragmentation and cisplatin sensitivity. Serum deprivation increased ATAD3A expression and drug resistance. These results suggest that ATAD3A could be an anti-apoptotic marker in LADC. |
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| AbstractList | AAA domain-containing 3A (ATAD3A) is a member of the AAA-ATPase family. Three forms of ATAD3 have been identified: ATAD3A, ATAD3B and ATAD3C. In this study, we examined the type and expression of ATAD3 in lung adenocarcinoma (LADC). Expression of ATAD3A was detected by reverse transcription-polymerase chain reaction, immunoblotting, immunohistochemistry and confocal immunofluorescent microscopy. Our results show that ATAD3A is the major form expressed in LADC. Silencing of ATAD3A expression increased mitochondrial fragmentation and cisplatin sensitivity. Serum deprivation increased ATAD3A expression and drug resistance. These results suggest that ATAD3A could be an anti-apoptotic marker in LADC. AAA domain-containing 3A (ATAD3A) is a member of the AAA-ATPase family. Three forms of ATAD3 have been identified: ATAD3A, ATAD3B and ATAD3C. In this study, we examined the type and expression of ATAD3 in lung adenocarcinoma (LADC). Expression of ATAD3A was detected by reverse transcription-polymerase chain reaction, immunoblotting, immunohistochemistry and confocal immunofluorescent microscopy. Our results show that ATAD3A is the major form expressed in LADC. Silencing of ATAD3A expression increased mitochondrial fragmentation and cisplatin sensitivity. Serum deprivation increased ATAD3A expression and drug resistance. These results suggest that ATAD3A could be an anti-apoptotic marker in LADC.AAA domain-containing 3A (ATAD3A) is a member of the AAA-ATPase family. Three forms of ATAD3 have been identified: ATAD3A, ATAD3B and ATAD3C. In this study, we examined the type and expression of ATAD3 in lung adenocarcinoma (LADC). Expression of ATAD3A was detected by reverse transcription-polymerase chain reaction, immunoblotting, immunohistochemistry and confocal immunofluorescent microscopy. Our results show that ATAD3A is the major form expressed in LADC. Silencing of ATAD3A expression increased mitochondrial fragmentation and cisplatin sensitivity. Serum deprivation increased ATAD3A expression and drug resistance. These results suggest that ATAD3A could be an anti-apoptotic marker in LADC. |
| Author | Huang, Chih-Yang Ko, Wen-Je Sugano, Sumio Hsu, Shu-Han Huang, Chun-Hua Fang, Hsin-Yuan Lin, Tze-Yi Chiang, Shu-Fen Chiou, Shiow-Her Chang, Chia-Ling Chen, Chih-Yi Hsiao, Yi-Ting Hsu, Wen-Hu Chow, Kuan-Chih Lin, Ching-Yuang Chiang, I. Ping |
| Author_xml | – sequence: 1 fullname: Fang, Hsin-Yuan – sequence: 2 fullname: Chang, Chia-Ling – sequence: 3 fullname: Hsu, Shu-Han – sequence: 4 fullname: Huang, Chih-Yang – sequence: 5 fullname: Chiang, Shu-Fen – sequence: 6 fullname: Chiou, Shiow-Her – sequence: 7 fullname: Huang, Chun-Hua – sequence: 8 fullname: Hsiao, Yi-Ting – sequence: 9 fullname: Lin, Tze-Yi – sequence: 10 fullname: Chiang, I. Ping – sequence: 11 fullname: Hsu, Wen-Hu – sequence: 12 fullname: Sugano, Sumio – sequence: 13 fullname: Chen, Chih-Yi – sequence: 14 fullname: Lin, Ching-Yuang – sequence: 15 fullname: Ko, Wen-Je – sequence: 16 fullname: Chow, Kuan-Chih |
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| SubjectTerms | Adenocarcinoma - drug therapy Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - pathology Adenosine Triphosphatases - genetics Adenosine Triphosphatases - metabolism Apoptosis - drug effects Apoptosis - genetics Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism ATPases Associated with Diverse Cellular Activities Cisplatin - pharmacology Disease Progression Drug Resistance - genetics Female HeLa Cells Humans Immunohistochemistry Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Male Membrane Proteins - genetics Membrane Proteins - metabolism Microscopy, Fluorescence Mitochondria - drug effects Mitochondria - genetics Mitochondria - ultrastructure Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Neoplasm Staging RNA, Small Interfering - genetics Sequence Analysis, DNA |
| Title | ATPase family AAA domain-containing 3A is a novel anti-apoptotic factor in lung adenocarcinoma cells |
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