Proximity extension assay proteomics and renal single cell transcriptomics uncover novel urinary biomarkers for active lupus nephritis

• Published in: Journal of autoimmunity Vol. 143; p. 103165
• Main Authors: Li, Yaxi, Tang, Chenling, Vanarsa, Kamala, Thai, Nga, Castillo, Jessica, Lea, Gabrielle Alexis Braza, Lee, Kyung Hyun, Kim, Soojin, Pedroza, Claudia, Wu, Tianfu, Saxena, Ramesh, Mok, Chi Chiu, Mohan, Chandra
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.02.2024
• Subjects: Biomarker; Lupus nephritis; Proximity extension assay; Transcriptomics; Biomarker; Lupus nephritis; Transcriptomics; Proximity extension assay

To identify urinary biomarkers that can distinguish active renal involvement in Lupus Nephritis (LN), a severe manifestation of systemic lupus erythematosus (SLE). Urine from 117 subjects, comprised of inactive SLE, active non-renal lupus, active LN, and healthy controls, were subjected to Proximity...