Notch4 Inhibition Suppresses Invasion and Vasculogenic Mimicry Formation of Hepatocellular Carcinoma Cells

• Published in: Current medical science Vol. 37; no. 5; pp. 719 - 725
• Main Author: 程锐;蔡欣然;柯坤;陈燕凌
• Format: Journal Article
• Language: English
• Published: Wuhan Huazhong University of Science and Technology 01.10.2017; Department of Hepatobiliary Surgery, Union Hospital, Fujian Medical University, Fuzhou 350001, China%Department of Interventional Radiology, Union Hospital, Fujian Medical University, Fuzhou 350001, China
• Subjects: Medicine; Medicine & Public Health; Notch4; matrix metalloproteinase; invasion; vasculogenic mimicry; hepatocellular carcinoma

Vasculogenic mimicry（VM） is a process by which aggressive tumor cells generate non-endothelial cell-lined channels in malignant tumors including hepatocellular carcinoma（HCC）. It has provided new insights into tumor behavior and has surfaced as a potential target for drug therapy. The molecular even...