Highly Selective Intraportal Transplantation of Pancreatic Islets

• Published in: The Journal of surgical research Vol. 157; no. 2; pp. 216 - 222
• Main Authors: Juszczak, Maciej T., Ph.D, Kooner, Paul, M.B.B.S, Pawelec, Krystian, Ph.D, Jones, Gareth L., Ph.D, Hughes, Stephen J., Ph.D, Kumar, Anila, Ph.D, Powis, Stephen H., Ph.D, Press, Martin, F.R.C.P
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2009
• Subjects: Animals; Blood Glucose - metabolism; Dextrans; diabetes; Diabetes Mellitus, Experimental - blood; Diabetes Mellitus, Experimental - surgery; digital image analysis; Disease Models, Animal; graft survival; Graft Survival - physiology; histology; Injections, Intravenous - methods; intraportal transplantation; islets; Islets of Langerhans Transplantation - methods; Islets of Langerhans Transplantation - pathology; Liver - pathology; Male; Microspheres; Organ Size - physiology; Portal Vein; rat; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; selective transplantation; Streptozocin; Surgery; transplantation; Treatment Outcome; intraportal transplantation; rat; histology; islets; transplantation; graft survival; animals; diabetes; digital image analysis; selective transplantation

Background Histological assessment of intraportally transplanted islets in experimental rodent models is limited by the wide dissemination of islets throughout the liver. We describe a technique of highly selective intraportal islet transplantation, which increases the density of transplanted islets...