Altered Fat Differentiation and Adipocytokine Expression are Inter-Related and Linked to Morphological Changes and Insulin Resistance in HIV-1-Infected Lipodystrophic Patients

• Published in: Antiviral therapy Vol. 9; no. 4; pp. 555 - 564
• Main Authors: Jan, Véronique, Cervera, Pascale, Maachi, Mustapha, Baudrimont, Marielle, Kim, Minji, Vidal, Hubert, Girard, Pierre-Marie, Levan, Philippe, Rozenbaum, Willy, Lombès, Anne, Capeau, Jacqueline, Bastard, Jean-Philippe
• Format: Journal Article
• Language: English
• Published: London International Medical Press 01.08.2004
• Subjects: Adipocytes - metabolism; Adiponectin; Adipose Tissue - metabolism; Adipose Tissue - pathology; Adult; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral agents; Apoptosis; Biological and medical sciences; Blood Vessels - pathology; CCAAT-Enhancer-Binding Protein-alpha - genetics; CCAAT-Enhancer-Binding Protein-alpha - metabolism; CCAAT-Enhancer-Binding Protein-beta - genetics; CCAAT-Enhancer-Binding Protein-beta - metabolism; CCAAT-Enhancer-Binding Proteins - genetics; CCAAT-Enhancer-Binding Proteins - metabolism; Cross-Sectional Studies; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Female; Fibrosis - pathology; HIV-1; HIV-Associated Lipodystrophy Syndrome - metabolism; HIV-Associated Lipodystrophy Syndrome - pathology; Humans; Insulin Resistance; Intercellular Signaling Peptides and Proteins - genetics; Intercellular Signaling Peptides and Proteins - metabolism; Interleukin-6 - genetics; Interleukin-6 - metabolism; Leptin - genetics; Leptin - metabolism; Life Sciences; Macrophages - pathology; Male; Medical sciences; Middle Aged; Pharmacology. Drug treatments; RNA, Messenger - analysis; Sterol Regulatory Element Binding Protein 1; Transcription Factors - genetics; Transcription Factors - metabolism; Tumor Necrosis Factor-alpha - genetics; Tumor Necrosis Factor-alpha - metabolism; Infection; Human; Immunopathology; Target tissue resistance; Viral disease; Fat; AIDS; Morphological change; Immune deficiency; Insulin

To achieve a better understand of the pathophysiology of HIV-related lipoatrophy, we compared the mRNA expression of adipocytokines in fat samples from patients and healthy HIV-seronegative controls together with fat morphology and we studied the relationship between changes in fat morphology, adipo...