Induction treatment with FOLFIRINOX or oxaliplatin-based doublet followed by long-course chemoradiotherapy and surgery in locally advanced rectal cancer. A systematic review and pooled analysis from phase II and III trials - Moretto, Roberto; Vetere, Guglielmo; Carullo, Martina; Ciracì, Paolo; Masi, Gianluca; Cremolini, Chiara (Cancer treatment reviews, 2024)
Keywords: Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Chemoradiotherapy - methods; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Fluorouracil - administration & dosage; Fluorouracil - therapeutic use; FOLFIRINOX; FOLFOX/CAPOX; Humans; Induction Chemotherapy - methods; Induction treatment; Irinotecan - administration & dosage; Irinotecan - therapeutic use; Leucovorin - administration & dosage; Leucovorin - therapeutic use; Locally advanced rectal cancer; Neoadjuvant Therapy - methods; Oxaliplatin - administration & dosage; Oxaliplatin - therapeutic use; Rectal Neoplasms - pathology; Rectal Neoplasms - therapy; Total neoadjuvant therapy; FOLFIRINOX; Locally advanced rectal cancer; Induction treatment; FOLFOX/CAPOX; Total neoadjuvant therapy