Single Nucleotide Polymorphisms in Tobacco Metabolism and DNA Repair Genes and Prognosis in Resected Non-Small-Cell Lung Cancer

Background If tobacco-related carcinogens are not inactivated or extruded from the cell, they can damage the DNA. Single nucleotide polymorphisms (SNPs) in genes involved in tobacco metabolism, DNA repair, and multidrug resistance have been related to lung cancer susceptibility. We examined 13 SNPs...

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Published inThe Journal of surgical research Vol. 167; no. 1; pp. e5 - e12
Main Authors Campayo, Marc, M.D, Viñolas, Nuria, M.D., Ph.D, Navarro, Alfons, Ph.D, Carcereny, Enric, M.D, Casas, Francesc, M.D., Ph.D, Gel, Bernat, M.Sc, Diaz, Tania, M.Sc, Gimferrer, Josep Maria, M.D., Ph.D, Marrades, Ramon M., M.D., Ph.D, Ramirez, Jose, M.D., Ph.D, Monzo, Mariano, M.D., Ph.D
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.05.2011
Subjects
Adult
Aged
Aged, 80 and over
Carcinoma, Non-Small-Cell Lung - genetics
Carcinoma, Non-Small-Cell Lung - mortality
Carcinoma, Non-Small-Cell Lung - surgery
DNA repair
DNA Repair - genetics
DNA, Neoplasm - genetics
Female
Humans
Kaplan-Meier Estimate
lung cancer
Lung Neoplasms - genetics
Lung Neoplasms - mortality
Lung Neoplasms - surgery
Male
Middle Aged
Multivariate Analysis
Nicotiana - metabolism
NSCLC
Polymorphism, Single Nucleotide - genetics
polymorphisms
Prognosis
Retrospective Studies
SNP
Surgery
Survival Rate
tobacco metabolism
lung cancer
tobacco metabolism
SNP
NSCLC
polymorphisms
DNA repair
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Abstract Background If tobacco-related carcinogens are not inactivated or extruded from the cell, they can damage the DNA. Single nucleotide polymorphisms (SNPs) in genes involved in tobacco metabolism, DNA repair, and multidrug resistance have been related to lung cancer susceptibility. We examined 13 SNPs in 10 of these genes and correlated the results with time to progression (TTP) and overall survival (OS) in 71 smoker or former smoker patients with resected non-small-cell lung cancer (NSCLC). Materials and Methods DNA was obtained from paraffin-embedded tumor. SNP analysis of the candidate genes was performed by allelic discrimination assay. Log-rank test, Kaplan-Meier plots, and Cox multivariate analysis were used to evaluate the association of TTP and survival with the SNPs evaluated. Results Patients with wild-type (wt) XPC rs2228001, wt CYP2C8 rs10509681, or non-wt NAT2 rs1799930 had a longer TTP. Patients with wt ERCC1 showed a nonsignificant trend towards longer TTP. No other relation between SNPs and TTP were observed. Patients harboring at least two unfavorable genotypes in these four genes had a shorter TTP and OS than patients with either one or no unfavorable genotypes. In the multivariate analysis, non-wt XPC rs2228001 and the presence of at least two unfavorable genotypes emerged as independent markers for shorter TTP. Conclusions SNPs in tobacco metabolism and DNA repair genes may influence the clinical outcome of resected NSCLC.
AbstractList If tobacco-related carcinogens are not inactivated or extruded from the cell, they can damage the DNA. Single nucleotide polymorphisms (SNPs) in genes involved in tobacco metabolism, DNA repair, and multidrug resistance have been related to lung cancer susceptibility. We examined 13 SNPs in 10 of these genes and correlated the results with time to progression (TTP) and overall survival (OS) in 71 smoker or former smoker patients with resected non-small-cell lung cancer (NSCLC). DNA was obtained from paraffin-embedded tumor. SNP analysis of the candidate genes was performed by allelic discrimination assay. Log-rank test, Kaplan-Meier plots, and Cox multivariate analysis were used to evaluate the association of TTP and survival with the SNPs evaluated. Patients with wild-type (wt) XPC rs2228001, wt CYP2C8 rs10509681, or non-wt NAT2 rs1799930 had a longer TTP. Patients with wt ERCC1 showed a nonsignificant trend towards longer TTP. No other relation between SNPs and TTP were observed. Patients harboring at least two unfavorable genotypes in these four genes had a shorter TTP and OS than patients with either one or no unfavorable genotypes. In the multivariate analysis, non-wt XPC rs2228001 and the presence of at least two unfavorable genotypes emerged as independent markers for shorter TTP. SNPs in tobacco metabolism and DNA repair genes may influence the clinical outcome of resected NSCLC.
Background If tobacco-related carcinogens are not inactivated or extruded from the cell, they can damage the DNA. Single nucleotide polymorphisms (SNPs) in genes involved in tobacco metabolism, DNA repair, and multidrug resistance have been related to lung cancer susceptibility. We examined 13 SNPs in 10 of these genes and correlated the results with time to progression (TTP) and overall survival (OS) in 71 smoker or former smoker patients with resected non-small-cell lung cancer (NSCLC). Materials and Methods DNA was obtained from paraffin-embedded tumor. SNP analysis of the candidate genes was performed by allelic discrimination assay. Log-rank test, Kaplan-Meier plots, and Cox multivariate analysis were used to evaluate the association of TTP and survival with the SNPs evaluated. Results Patients with wild-type (wt) XPC rs2228001, wt CYP2C8 rs10509681, or non-wt NAT2 rs1799930 had a longer TTP. Patients with wt ERCC1 showed a nonsignificant trend towards longer TTP. No other relation between SNPs and TTP were observed. Patients harboring at least two unfavorable genotypes in these four genes had a shorter TTP and OS than patients with either one or no unfavorable genotypes. In the multivariate analysis, non-wt XPC rs2228001 and the presence of at least two unfavorable genotypes emerged as independent markers for shorter TTP. Conclusions SNPs in tobacco metabolism and DNA repair genes may influence the clinical outcome of resected NSCLC.
Author Diaz, Tania, M.Sc
Marrades, Ramon M., M.D., Ph.D
Casas, Francesc, M.D., Ph.D
Gimferrer, Josep Maria, M.D., Ph.D
Gel, Bernat, M.Sc
Ramirez, Jose, M.D., Ph.D
Monzo, Mariano, M.D., Ph.D
Campayo, Marc, M.D
Navarro, Alfons, Ph.D
Viñolas, Nuria, M.D., Ph.D
Carcereny, Enric, M.D
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CitedBy_id crossref_primary_10_1038_s41598_017_10800_5
crossref_primary_10_1093_carcin_bgu142
crossref_primary_10_1002_cam4_822
crossref_primary_10_1038_s41598_018_33071_0
crossref_primary_10_1158_1078_0432_CCR_12_0191
Cites_doi 10.1016/j.lungcan.2007.02.002
10.3322/caac.20006
10.1097/00008571-199808000-00002
10.1080/03602530802186603
10.1093/carcin/bgi232
10.1093/aje/kwn417
10.1038/nrc1190
10.1089/dna.1996.15.273
10.1016/S0959-437X(96)80091-8
10.1093/carcin/bgn020
10.1002/lary.20254
10.1378/chest.127.3.978
10.1097/00008571-200110000-00006
10.1146/annurev.biochem.73.011303.073723
10.1289/ehp.97105s4791
10.1002/cncr.24042
10.1038/35094000
10.1183/09031936.97.10081837
10.1378/chest.122.3.1037
10.1056/NEJMoa060570
10.1002/ijc.11346
10.1080/02841860600902197
10.1056/NEJMoa060467
10.1046/j.1472-8206.2003.00119.x
10.1097/01.ede.0000187627.70026.23
10.1016/S0378-4274(01)00544-6
10.1080/00498250701867889
10.1093/annonc/mdh319
10.1056/NEJMoa031644
10.1016/S0140-6736(98)06341-7
10.1021/tx00043a018
10.1093/jnci/92.21.1764
10.1073/pnas.050585397
10.1093/jnci/91.14.1194
10.2174/0929867306666220208213032
10.1021/tx0002583
10.1016/j.cancergencyto.2005.07.003
10.1186/1465-9921-8-49
10.7150/ijms.4.59
10.1093/jnci/dji101
10.1016/j.lungcan.2010.05.005
10.1016/j.mrfmmm.2005.03.007
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Issue 1
Keywords lung cancer
tobacco metabolism
SNP
NSCLC
polymorphisms
DNA repair
Language English
License Copyright © 2011 Elsevier Inc. All rights reserved.
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References Bartsch, Nair, Risch (bib13) 2000; 9
Hashibe, Brennan, Strange (bib21) 2003; 12
Salinas, Wong (bib10) 1999; 6
Shen, Spitz, Qiao (bib27) 2003; 107
Pan, Han, Wu (bib43) 2007; 46
(bib4) 1998; 352
Wei, Cheng, Amos (bib26) 2000; 92
Lechapt-Zalcman, Hurbain, Lacave (bib31) 1997; 10
Bouchardy, Mitrunen, Wikman (bib37) 1998; 8
Bauer, Guo, Ueng (bib9) 1995; 8
Sim, Walters, Boukouvala (bib12) 2008; 40
Dai, Zeldin, Blaisdell (bib35) 2001; 11
Wang, Jin, Wang (bib33) 2009; 115
Brundage, Davies, Mackillop (bib2) 2002; 122
Kiyohara, Yoshimasu, Takayama (bib19) 2006; 17
Hoffmeyer, Burk, von Richter (bib30) 2000; 97
Sancar, Lindsey-Boltz, Unsal-Kaçmaz (bib8) 2004; 73
Zienolddiny, Campa, Lind (bib16) 2008; 29
Seidegård, Ekström (bib11) 1997; 105
Nebert, McKinnon, Puga (bib14) 1996; 15
van der Deen, Timens, Timmer-Bosscha (bib32) 2007; 8
Wood, Mitchell, Lindahl (bib22) 2005; 577
Daly (bib15) 2003; 17
Grau, Caballero, Campayo (bib34) 2009; 119
Olaussen, Dunant, Fouret (bib39) 2006; 355
Zienolddiny, Campa, Lind (bib25) 2006; 27
Zhou (bib29) 2008; 38
Friedberg (bib40) 2001; 1
Hecht (bib7) 1999; 91
Hein (bib20) 2002; 65
Kiyohara, Yoshimasu (bib23) 2007; 4
Yin, Vogel, Guo (bib41) 2006; 164
Guengerich (bib6) 2001; 14
Jemal, Siegel, Ward (bib1) 2009; 59
Hung, Brennan, Canzian (bib24) 2005; 97
Viñolas, Provencio, Reguart (bib44) 2011; 71
Hecht (bib5) 2003; 3
Isla, Sarries, Rosell (bib42) 2004; 15
Gresner, Gromadzinska, Wasowicz (bib17) 2007; 57
Gottesman, Pastan, Ambudkar (bib28) 1996; 6
Arriagada, Bergman, Dunant (bib3) 2004; 350
Simon, Sharma, Cantor (bib38) 2005; 127
Potti, Mukherjee, Petersen (bib45) 2006; 355
Cote, Chen, Smith (bib18) 2009; 169
Golka, Prior, Blaszkewicz (bib36) 2002; 128
Kiyohara (10.1016/j.jss.2011.01.007_bib19) 2006; 17
Guengerich (10.1016/j.jss.2011.01.007_bib6) 2001; 14
Hein (10.1016/j.jss.2011.01.007_bib20) 2002; 65
Kiyohara (10.1016/j.jss.2011.01.007_bib23) 2007; 4
Lechapt-Zalcman (10.1016/j.jss.2011.01.007_bib31) 1997; 10
Pan (10.1016/j.jss.2011.01.007_bib43) 2007; 46
Simon (10.1016/j.jss.2011.01.007_bib38) 2005; 127
Zienolddiny (10.1016/j.jss.2011.01.007_bib25) 2006; 27
Wood (10.1016/j.jss.2011.01.007_bib22) 2005; 577
Brundage (10.1016/j.jss.2011.01.007_bib2) 2002; 122
Golka (10.1016/j.jss.2011.01.007_bib36) 2002; 128
Nebert (10.1016/j.jss.2011.01.007_bib14) 1996; 15
Sancar (10.1016/j.jss.2011.01.007_bib8) 2004; 73
Salinas (10.1016/j.jss.2011.01.007_bib10) 1999; 6
Bouchardy (10.1016/j.jss.2011.01.007_bib37) 1998; 8
Gresner (10.1016/j.jss.2011.01.007_bib17) 2007; 57
Jemal (10.1016/j.jss.2011.01.007_bib1) 2009; 59
Viñolas (10.1016/j.jss.2011.01.007_bib44) 2011; 71
Hecht (10.1016/j.jss.2011.01.007_bib7) 1999; 91
Gottesman (10.1016/j.jss.2011.01.007_bib28) 1996; 6
Zienolddiny (10.1016/j.jss.2011.01.007_bib16) 2008; 29
Zhou (10.1016/j.jss.2011.01.007_bib29) 2008; 38
(10.1016/j.jss.2011.01.007_bib4) 1998; 352
Hecht (10.1016/j.jss.2011.01.007_bib5) 2003; 3
Yin (10.1016/j.jss.2011.01.007_bib41) 2006; 164
Hung (10.1016/j.jss.2011.01.007_bib24) 2005; 97
Cote (10.1016/j.jss.2011.01.007_bib18) 2009; 169
Wang (10.1016/j.jss.2011.01.007_bib33) 2009; 115
Sim (10.1016/j.jss.2011.01.007_bib12) 2008; 40
Hashibe (10.1016/j.jss.2011.01.007_bib21) 2003; 12
Shen (10.1016/j.jss.2011.01.007_bib27) 2003; 107
Dai (10.1016/j.jss.2011.01.007_bib35) 2001; 11
Olaussen (10.1016/j.jss.2011.01.007_bib39) 2006; 355
van der Deen (10.1016/j.jss.2011.01.007_bib32) 2007; 8
Bauer (10.1016/j.jss.2011.01.007_bib9) 1995; 8
Grau (10.1016/j.jss.2011.01.007_bib34) 2009; 119
Bartsch (10.1016/j.jss.2011.01.007_bib13) 2000; 9
Arriagada (10.1016/j.jss.2011.01.007_bib3) 2004; 350
Seidegård (10.1016/j.jss.2011.01.007_bib11) 1997; 105
Potti (10.1016/j.jss.2011.01.007_bib45) 2006; 355
Friedberg (10.1016/j.jss.2011.01.007_bib40) 2001; 1
Wei (10.1016/j.jss.2011.01.007_bib26) 2000; 92
Hoffmeyer (10.1016/j.jss.2011.01.007_bib30) 2000; 97
Isla (10.1016/j.jss.2011.01.007_bib42) 2004; 15
Daly (10.1016/j.jss.2011.01.007_bib15) 2003; 17
References_xml – volume: 169
  start-page: 802
  year: 2009
  ident: bib18
  article-title: Meta- and pooled analysis of GSTP1 polymorphism and lung cancer: A HuGE-GSEC review
  publication-title: Am J Epidemiol
  contributor:
    fullname: Smith
– volume: 46
  start-page: 361
  year: 2007
  ident: bib43
  article-title: CYP450 polymorphisms predict clinic outcomes to vinorelbine-based chemotherapy in patients with non-small-cell lung cancer
  publication-title: Acta Oncol
  contributor:
    fullname: Wu
– volume: 97
  start-page: 3473
  year: 2000
  ident: bib30
  article-title: Functional polymorphisms of the human multidrug resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity
  publication-title: Proc Natl Acad Sci USA
  contributor:
    fullname: von Richter
– volume: 115
  start-page: 595
  year: 2009
  ident: bib33
  article-title: Genetic susceptibility of lung cancer associated with common variants in the 3’ untranslated regions of the adenosine triphosphate-binding cassette B1 (ABCB1) and ABCC1 candidate transporter genes for carcinogen export
  publication-title: Cancer
  contributor:
    fullname: Wang
– volume: 127
  start-page: 978
  year: 2005
  ident: bib38
  article-title: ERCC1 expression is a predictor of survival in resected patients with non-small cell lung cancer
  publication-title: Chest
  contributor:
    fullname: Cantor
– volume: 9
  start-page: 3
  year: 2000
  ident: bib13
  article-title: Genetic polymorphism of CYP genes, alone or in combination, as a risk modifier of tobacco-related cancers
  publication-title: Cancer Epidemiol Biomarkers Prev
  contributor:
    fullname: Risch
– volume: 38
  start-page: 802
  year: 2008
  ident: bib29
  article-title: Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition
  publication-title: Xenobiotica
  contributor:
    fullname: Zhou
– volume: 71
  start-page: 191
  year: 2011
  ident: bib44
  article-title: Single nucleotide polymorphisms in MDR1 gene correlates with outcome in advanced non-small-cell lung cancer patients treated with cisplatin plus vinorelbine
  publication-title: Lung Cancer
  contributor:
    fullname: Reguart
– volume: 352
  start-page: 257
  year: 1998
  ident: bib4
  article-title: PORT Meta-Analysis Trialist Group: Postoperative radiotherapy in non-small cell lung cancer: Systemic review and meta-analysis of individual patient data from nine randomized controlled trials
  publication-title: Lancet
– volume: 15
  start-page: 1194
  year: 2004
  ident: bib42
  article-title: Single nucleotide polymorphisms and outcome in docetaxel-cisplatin-treated advanced non-small-cell lung cancer
  publication-title: Ann Oncol
  contributor:
    fullname: Rosell
– volume: 97
  start-page: 567
  year: 2005
  ident: bib24
  article-title: Large-scale investigation of base excision repair genetic polymorphisms and lung cancer risk in a multicenter study
  publication-title: J Natl Cancer Inst
  contributor:
    fullname: Canzian
– volume: 1
  start-page: 223
  year: 2001
  ident: bib40
  article-title: How nucleotide excision repair protects against cancer
  publication-title: Nat Rev Cancer
  contributor:
    fullname: Friedberg
– volume: 40
  start-page: 479
  year: 2008
  ident: bib12
  article-title: Arylamine
  publication-title: Drug Metab Rev
  contributor:
    fullname: Boukouvala
– volume: 164
  start-page: 66
  year: 2006
  ident: bib41
  article-title: Lack of association between DNA repair gene ERCC1 polymorphism and risk of lung cancer in a Chinese population
  publication-title: Cancer Genet Cytogenet
  contributor:
    fullname: Guo
– volume: 15
  start-page: 273
  year: 1996
  ident: bib14
  article-title: Human drug-metabolizing enzyme polymorphisms: Effects on risk of toxicity and cancer
  publication-title: DNA Cell Biol
  contributor:
    fullname: Puga
– volume: 105
  start-page: 791
  year: 1997
  ident: bib11
  article-title: The role of human glutathione transferases and epoxide hydrolases in the metabolism of xenobiotics
  publication-title: Environ Health Perspect
  contributor:
    fullname: Ekström
– volume: 91
  start-page: 1194
  year: 1999
  ident: bib7
  article-title: Tobacco smoke carcinogens and lung cancer
  publication-title: J Natl Cancer Inst
  contributor:
    fullname: Hecht
– volume: 12
  start-page: 1509
  year: 2003
  ident: bib21
  article-title: Meta- and pooled analyses of GSTM1, GSTT1, GSTP1, and CYP1A1 genotypes and risk of head and neck cancer
  publication-title: Cancer Epidemiol Biomarkers Prev
  contributor:
    fullname: Strange
– volume: 6
  start-page: 610
  year: 1996
  ident: bib28
  article-title: P-glycoprotein and multidrug resistance
  publication-title: Curr Opin Genet Dev
  contributor:
    fullname: Ambudkar
– volume: 6
  start-page: 279
  year: 1999
  ident: bib10
  article-title: Glutathione S-transferases—A review
  publication-title: Curr Med Chem
  contributor:
    fullname: Wong
– volume: 65
  start-page: 506
  year: 2002
  ident: bib20
  article-title: Molecular genetics and function of NAT1 and NAT2: Role in aromatic amine metabolism and carcinogenesis
  publication-title: Mutat Res
  contributor:
    fullname: Hein
– volume: 350
  start-page: 351
  year: 2004
  ident: bib3
  article-title: Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer
  publication-title: N Engl J Med
  contributor:
    fullname: Dunant
– volume: 11
  start-page: 597
  year: 2001
  ident: bib35
  article-title: Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid
  publication-title: Pharmacogenetics
  contributor:
    fullname: Blaisdell
– volume: 29
  start-page: 1164
  year: 2008
  ident: bib16
  article-title: A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of non-small-cell lung cancer in smokers
  publication-title: Carcinogenesis
  contributor:
    fullname: Lind
– volume: 119
  start-page: 1484
  year: 2009
  ident: bib34
  article-title: Gene single nucleotide polymorphism accumulation improves survival in advanced head and neck cancer patients treated with weekly paclitaxel
  publication-title: Laryngoscope
  contributor:
    fullname: Campayo
– volume: 355
  start-page: 983
  year: 2006
  ident: bib39
  article-title: DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy
  publication-title: N Engl J Med
  contributor:
    fullname: Fouret
– volume: 10
  start-page: 1837
  year: 1997
  ident: bib31
  article-title: MDR1-Pgp 170 expression in human bronchus
  publication-title: Eur Respir J
  contributor:
    fullname: Lacave
– volume: 355
  start-page: 570
  year: 2006
  ident: bib45
  article-title: A genomic strategy to refine prognosis in early-stage non-small-cell lung cancer
  publication-title: N Engl J Med
  contributor:
    fullname: Petersen
– volume: 3
  start-page: 733
  year: 2003
  ident: bib5
  article-title: Tobacco carcinogens, their biomarkers, and tobacco-induced cancer
  publication-title: Nat Rev Cancer
  contributor:
    fullname: Hecht
– volume: 73
  start-page: 39
  year: 2004
  ident: bib8
  article-title: Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
  publication-title: Annu Rev Biochem
  contributor:
    fullname: Unsal-Kaçmaz
– volume: 92
  start-page: 1764
  year: 2000
  ident: bib26
  article-title: Repair of tobacco carcinogen-induced DNA adducts and lung cancer risk: A molecular epidemiologic study
  publication-title: J Natl Cancer Inst
  contributor:
    fullname: Amos
– volume: 8
  start-page: 136
  year: 1995
  ident: bib9
  article-title: Oxidation of benzo[a]pyrene by recombinant human cytochrome P450 enzymes
  publication-title: Chem Res Toxicol
  contributor:
    fullname: Ueng
– volume: 4
  start-page: 59
  year: 2007
  ident: bib23
  article-title: Genetic polymorphisms in the nucleotide excision repair pathway and lung cancer risk: A meta-analysis
  publication-title: Int J Med Sci
  contributor:
    fullname: Yoshimasu
– volume: 27
  start-page: 560
  year: 2006
  ident: bib25
  article-title: Polymorphisms of DNA repair genes and risk of non-small cell lung cancer
  publication-title: Carcinogenesis
  contributor:
    fullname: Lind
– volume: 8
  start-page: 291
  year: 1998
  ident: bib37
  article-title: N-acetyltransferase NAT1 and NAT2 genotypes and lung cancer risk
  publication-title: Pharmacogenetics
  contributor:
    fullname: Wikman
– volume: 14
  start-page: 611
  year: 2001
  ident: bib6
  article-title: Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity
  publication-title: Chem Res Toxicol
  contributor:
    fullname: Guengerich
– volume: 17
  start-page: 27
  year: 2003
  ident: bib15
  article-title: Pharmacogenetics of the major polymorphic metabolizing enzymes
  publication-title: Fundam Clin Pharmacol
  contributor:
    fullname: Daly
– volume: 59
  start-page: 225
  year: 2009
  ident: bib1
  article-title: Cancer statistics, 2009
  publication-title: Ca Cancer J Clin
  contributor:
    fullname: Ward
– volume: 577
  start-page: 275
  year: 2005
  ident: bib22
  article-title: Human DNA repair genes
  publication-title: Mutation Res
  contributor:
    fullname: Lindahl
– volume: 8
  start-page: 49
  year: 2007
  ident: bib32
  article-title: Reduced inflammatory response in cigarette smoke exposed Mrp1/Mdr1a/1b deficient mice
  publication-title: Respir Res
  contributor:
    fullname: Timmer-Bosscha
– volume: 128
  start-page: 229
  year: 2002
  ident: bib36
  article-title: The enhanced bladder cancer susceptibility of NAT2 slow acetylators towards aromatic amines: A review considering ethnic differences
  publication-title: Toxicol Lett
  contributor:
    fullname: Blaszkewicz
– volume: 122
  start-page: 1037
  year: 2002
  ident: bib2
  article-title: Prognostic factors in non-small-cell lung cancer: A decade of progress
  publication-title: Chest
  contributor:
    fullname: Mackillop
– volume: 57
  start-page: 1
  year: 2007
  ident: bib17
  article-title: Polymorphism of selected enzymes involved in detoxification and biotransformation in relation to lung cancer
  publication-title: Lung Cancer
  contributor:
    fullname: Wasowicz
– volume: 17
  start-page: 89
  year: 2006
  ident: bib19
  article-title: EPHX1 polymorphisms and the risk of lung cancer
  publication-title: Epidemiology
  contributor:
    fullname: Takayama
– volume: 107
  start-page: 84
  year: 2003
  ident: bib27
  article-title: Smoking, DNA repair capacity and risk of nonsmall cell lung cancer
  publication-title: Int J Cancer
  contributor:
    fullname: Qiao
– volume: 57
  start-page: 1
  year: 2007
  ident: 10.1016/j.jss.2011.01.007_bib17
  article-title: Polymorphism of selected enzymes involved in detoxification and biotransformation in relation to lung cancer
  publication-title: Lung Cancer
  doi: 10.1016/j.lungcan.2007.02.002
  contributor:
    fullname: Gresner
– volume: 59
  start-page: 225
  year: 2009
  ident: 10.1016/j.jss.2011.01.007_bib1
  article-title: Cancer statistics, 2009
  publication-title: Ca Cancer J Clin
  doi: 10.3322/caac.20006
  contributor:
    fullname: Jemal
– volume: 8
  start-page: 291
  year: 1998
  ident: 10.1016/j.jss.2011.01.007_bib37
  article-title: N-acetyltransferase NAT1 and NAT2 genotypes and lung cancer risk
  publication-title: Pharmacogenetics
  doi: 10.1097/00008571-199808000-00002
  contributor:
    fullname: Bouchardy
– volume: 9
  start-page: 3
  year: 2000
  ident: 10.1016/j.jss.2011.01.007_bib13
  article-title: Genetic polymorphism of CYP genes, alone or in combination, as a risk modifier of tobacco-related cancers
  publication-title: Cancer Epidemiol Biomarkers Prev
  contributor:
    fullname: Bartsch
– volume: 40
  start-page: 479
  year: 2008
  ident: 10.1016/j.jss.2011.01.007_bib12
  article-title: Arylamine N-acetyltransferases: From structure to function
  publication-title: Drug Metab Rev
  doi: 10.1080/03602530802186603
  contributor:
    fullname: Sim
– volume: 27
  start-page: 560
  year: 2006
  ident: 10.1016/j.jss.2011.01.007_bib25
  article-title: Polymorphisms of DNA repair genes and risk of non-small cell lung cancer
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgi232
  contributor:
    fullname: Zienolddiny
– volume: 169
  start-page: 802
  year: 2009
  ident: 10.1016/j.jss.2011.01.007_bib18
  article-title: Meta- and pooled analysis of GSTP1 polymorphism and lung cancer: A HuGE-GSEC review
  publication-title: Am J Epidemiol
  doi: 10.1093/aje/kwn417
  contributor:
    fullname: Cote
– volume: 3
  start-page: 733
  year: 2003
  ident: 10.1016/j.jss.2011.01.007_bib5
  article-title: Tobacco carcinogens, their biomarkers, and tobacco-induced cancer
  publication-title: Nat Rev Cancer
  doi: 10.1038/nrc1190
  contributor:
    fullname: Hecht
– volume: 15
  start-page: 273
  year: 1996
  ident: 10.1016/j.jss.2011.01.007_bib14
  article-title: Human drug-metabolizing enzyme polymorphisms: Effects on risk of toxicity and cancer
  publication-title: DNA Cell Biol
  doi: 10.1089/dna.1996.15.273
  contributor:
    fullname: Nebert
– volume: 6
  start-page: 610
  year: 1996
  ident: 10.1016/j.jss.2011.01.007_bib28
  article-title: P-glycoprotein and multidrug resistance
  publication-title: Curr Opin Genet Dev
  doi: 10.1016/S0959-437X(96)80091-8
  contributor:
    fullname: Gottesman
– volume: 29
  start-page: 1164
  year: 2008
  ident: 10.1016/j.jss.2011.01.007_bib16
  article-title: A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of non-small-cell lung cancer in smokers
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgn020
  contributor:
    fullname: Zienolddiny
– volume: 119
  start-page: 1484
  year: 2009
  ident: 10.1016/j.jss.2011.01.007_bib34
  article-title: Gene single nucleotide polymorphism accumulation improves survival in advanced head and neck cancer patients treated with weekly paclitaxel
  publication-title: Laryngoscope
  doi: 10.1002/lary.20254
  contributor:
    fullname: Grau
– volume: 127
  start-page: 978
  year: 2005
  ident: 10.1016/j.jss.2011.01.007_bib38
  article-title: ERCC1 expression is a predictor of survival in resected patients with non-small cell lung cancer
  publication-title: Chest
  doi: 10.1378/chest.127.3.978
  contributor:
    fullname: Simon
– volume: 11
  start-page: 597
  year: 2001
  ident: 10.1016/j.jss.2011.01.007_bib35
  article-title: Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid
  publication-title: Pharmacogenetics
  doi: 10.1097/00008571-200110000-00006
  contributor:
    fullname: Dai
– volume: 73
  start-page: 39
  year: 2004
  ident: 10.1016/j.jss.2011.01.007_bib8
  article-title: Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
  publication-title: Annu Rev Biochem
  doi: 10.1146/annurev.biochem.73.011303.073723
  contributor:
    fullname: Sancar
– volume: 12
  start-page: 1509
  year: 2003
  ident: 10.1016/j.jss.2011.01.007_bib21
  article-title: Meta- and pooled analyses of GSTM1, GSTT1, GSTP1, and CYP1A1 genotypes and risk of head and neck cancer
  publication-title: Cancer Epidemiol Biomarkers Prev
  contributor:
    fullname: Hashibe
– volume: 105
  start-page: 791
  year: 1997
  ident: 10.1016/j.jss.2011.01.007_bib11
  article-title: The role of human glutathione transferases and epoxide hydrolases in the metabolism of xenobiotics
  publication-title: Environ Health Perspect
  doi: 10.1289/ehp.97105s4791
  contributor:
    fullname: Seidegård
– volume: 115
  start-page: 595
  year: 2009
  ident: 10.1016/j.jss.2011.01.007_bib33
  article-title: Genetic susceptibility of lung cancer associated with common variants in the 3’ untranslated regions of the adenosine triphosphate-binding cassette B1 (ABCB1) and ABCC1 candidate transporter genes for carcinogen export
  publication-title: Cancer
  doi: 10.1002/cncr.24042
  contributor:
    fullname: Wang
– volume: 1
  start-page: 223
  year: 2001
  ident: 10.1016/j.jss.2011.01.007_bib40
  article-title: How nucleotide excision repair protects against cancer
  publication-title: Nat Rev Cancer
  doi: 10.1038/35094000
  contributor:
    fullname: Friedberg
– volume: 10
  start-page: 1837
  year: 1997
  ident: 10.1016/j.jss.2011.01.007_bib31
  article-title: MDR1-Pgp 170 expression in human bronchus
  publication-title: Eur Respir J
  doi: 10.1183/09031936.97.10081837
  contributor:
    fullname: Lechapt-Zalcman
– volume: 122
  start-page: 1037
  year: 2002
  ident: 10.1016/j.jss.2011.01.007_bib2
  article-title: Prognostic factors in non-small-cell lung cancer: A decade of progress
  publication-title: Chest
  doi: 10.1378/chest.122.3.1037
  contributor:
    fullname: Brundage
– volume: 355
  start-page: 983
  year: 2006
  ident: 10.1016/j.jss.2011.01.007_bib39
  article-title: DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa060570
  contributor:
    fullname: Olaussen
– volume: 107
  start-page: 84
  year: 2003
  ident: 10.1016/j.jss.2011.01.007_bib27
  article-title: Smoking, DNA repair capacity and risk of nonsmall cell lung cancer
  publication-title: Int J Cancer
  doi: 10.1002/ijc.11346
  contributor:
    fullname: Shen
– volume: 46
  start-page: 361
  year: 2007
  ident: 10.1016/j.jss.2011.01.007_bib43
  article-title: CYP450 polymorphisms predict clinic outcomes to vinorelbine-based chemotherapy in patients with non-small-cell lung cancer
  publication-title: Acta Oncol
  doi: 10.1080/02841860600902197
  contributor:
    fullname: Pan
– volume: 355
  start-page: 570
  year: 2006
  ident: 10.1016/j.jss.2011.01.007_bib45
  article-title: A genomic strategy to refine prognosis in early-stage non-small-cell lung cancer
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa060467
  contributor:
    fullname: Potti
– volume: 17
  start-page: 27
  year: 2003
  ident: 10.1016/j.jss.2011.01.007_bib15
  article-title: Pharmacogenetics of the major polymorphic metabolizing enzymes
  publication-title: Fundam Clin Pharmacol
  doi: 10.1046/j.1472-8206.2003.00119.x
  contributor:
    fullname: Daly
– volume: 17
  start-page: 89
  year: 2006
  ident: 10.1016/j.jss.2011.01.007_bib19
  article-title: EPHX1 polymorphisms and the risk of lung cancer
  publication-title: Epidemiology
  doi: 10.1097/01.ede.0000187627.70026.23
  contributor:
    fullname: Kiyohara
– volume: 128
  start-page: 229
  year: 2002
  ident: 10.1016/j.jss.2011.01.007_bib36
  article-title: The enhanced bladder cancer susceptibility of NAT2 slow acetylators towards aromatic amines: A review considering ethnic differences
  publication-title: Toxicol Lett
  doi: 10.1016/S0378-4274(01)00544-6
  contributor:
    fullname: Golka
– volume: 38
  start-page: 802
  year: 2008
  ident: 10.1016/j.jss.2011.01.007_bib29
  article-title: Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition
  publication-title: Xenobiotica
  doi: 10.1080/00498250701867889
  contributor:
    fullname: Zhou
– volume: 15
  start-page: 1194
  year: 2004
  ident: 10.1016/j.jss.2011.01.007_bib42
  article-title: Single nucleotide polymorphisms and outcome in docetaxel-cisplatin-treated advanced non-small-cell lung cancer
  publication-title: Ann Oncol
  doi: 10.1093/annonc/mdh319
  contributor:
    fullname: Isla
– volume: 350
  start-page: 351
  year: 2004
  ident: 10.1016/j.jss.2011.01.007_bib3
  article-title: Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa031644
  contributor:
    fullname: Arriagada
– volume: 352
  start-page: 257
  year: 1998
  ident: 10.1016/j.jss.2011.01.007_bib4
  article-title: PORT Meta-Analysis Trialist Group: Postoperative radiotherapy in non-small cell lung cancer: Systemic review and meta-analysis of individual patient data from nine randomized controlled trials
  publication-title: Lancet
  doi: 10.1016/S0140-6736(98)06341-7
– volume: 8
  start-page: 136
  year: 1995
  ident: 10.1016/j.jss.2011.01.007_bib9
  article-title: Oxidation of benzo[a]pyrene by recombinant human cytochrome P450 enzymes
  publication-title: Chem Res Toxicol
  doi: 10.1021/tx00043a018
  contributor:
    fullname: Bauer
– volume: 92
  start-page: 1764
  year: 2000
  ident: 10.1016/j.jss.2011.01.007_bib26
  article-title: Repair of tobacco carcinogen-induced DNA adducts and lung cancer risk: A molecular epidemiologic study
  publication-title: J Natl Cancer Inst
  doi: 10.1093/jnci/92.21.1764
  contributor:
    fullname: Wei
– volume: 97
  start-page: 3473
  year: 2000
  ident: 10.1016/j.jss.2011.01.007_bib30
  article-title: Functional polymorphisms of the human multidrug resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.050585397
  contributor:
    fullname: Hoffmeyer
– volume: 91
  start-page: 1194
  year: 1999
  ident: 10.1016/j.jss.2011.01.007_bib7
  article-title: Tobacco smoke carcinogens and lung cancer
  publication-title: J Natl Cancer Inst
  doi: 10.1093/jnci/91.14.1194
  contributor:
    fullname: Hecht
– volume: 65
  start-page: 506
  year: 2002
  ident: 10.1016/j.jss.2011.01.007_bib20
  article-title: Molecular genetics and function of NAT1 and NAT2: Role in aromatic amine metabolism and carcinogenesis
  publication-title: Mutat Res
  contributor:
    fullname: Hein
– volume: 6
  start-page: 279
  year: 1999
  ident: 10.1016/j.jss.2011.01.007_bib10
  article-title: Glutathione S-transferases—A review
  publication-title: Curr Med Chem
  doi: 10.2174/0929867306666220208213032
  contributor:
    fullname: Salinas
– volume: 14
  start-page: 611
  year: 2001
  ident: 10.1016/j.jss.2011.01.007_bib6
  article-title: Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity
  publication-title: Chem Res Toxicol
  doi: 10.1021/tx0002583
  contributor:
    fullname: Guengerich
– volume: 164
  start-page: 66
  year: 2006
  ident: 10.1016/j.jss.2011.01.007_bib41
  article-title: Lack of association between DNA repair gene ERCC1 polymorphism and risk of lung cancer in a Chinese population
  publication-title: Cancer Genet Cytogenet
  doi: 10.1016/j.cancergencyto.2005.07.003
  contributor:
    fullname: Yin
– volume: 8
  start-page: 49
  year: 2007
  ident: 10.1016/j.jss.2011.01.007_bib32
  article-title: Reduced inflammatory response in cigarette smoke exposed Mrp1/Mdr1a/1b deficient mice
  publication-title: Respir Res
  doi: 10.1186/1465-9921-8-49
  contributor:
    fullname: van der Deen
– volume: 4
  start-page: 59
  year: 2007
  ident: 10.1016/j.jss.2011.01.007_bib23
  article-title: Genetic polymorphisms in the nucleotide excision repair pathway and lung cancer risk: A meta-analysis
  publication-title: Int J Med Sci
  doi: 10.7150/ijms.4.59
  contributor:
    fullname: Kiyohara
– volume: 97
  start-page: 567
  year: 2005
  ident: 10.1016/j.jss.2011.01.007_bib24
  article-title: Large-scale investigation of base excision repair genetic polymorphisms and lung cancer risk in a multicenter study
  publication-title: J Natl Cancer Inst
  doi: 10.1093/jnci/dji101
  contributor:
    fullname: Hung
– volume: 71
  start-page: 191
  year: 2011
  ident: 10.1016/j.jss.2011.01.007_bib44
  article-title: Single nucleotide polymorphisms in MDR1 gene correlates with outcome in advanced non-small-cell lung cancer patients treated with cisplatin plus vinorelbine
  publication-title: Lung Cancer
  doi: 10.1016/j.lungcan.2010.05.005
  contributor:
    fullname: Viñolas
– volume: 577
  start-page: 275
  year: 2005
  ident: 10.1016/j.jss.2011.01.007_bib22
  article-title: Human DNA repair genes
  publication-title: Mutation Res
  doi: 10.1016/j.mrfmmm.2005.03.007
  contributor:
    fullname: Wood
SSID ssj0002973
Score 2.0268588
Snippet Background If tobacco-related carcinogens are not inactivated or extruded from the cell, they can damage the DNA. Single nucleotide polymorphisms (SNPs) in...
If tobacco-related carcinogens are not inactivated or extruded from the cell, they can damage the DNA. Single nucleotide polymorphisms (SNPs) in genes involved...
SourceID crossref
pubmed
elsevier
SourceType Aggregation Database
Index Database
Publisher
StartPage e5
SubjectTerms Adult
Aged
Aged, 80 and over
Carcinoma, Non-Small-Cell Lung - genetics
Carcinoma, Non-Small-Cell Lung - mortality
Carcinoma, Non-Small-Cell Lung - surgery
DNA repair
DNA Repair - genetics
DNA, Neoplasm - genetics
Female
Humans
Kaplan-Meier Estimate
lung cancer
Lung Neoplasms - genetics
Lung Neoplasms - mortality
Lung Neoplasms - surgery
Male
Middle Aged
Multivariate Analysis
Nicotiana - metabolism
NSCLC
Polymorphism, Single Nucleotide - genetics
polymorphisms
Prognosis
Retrospective Studies
SNP
Surgery
Survival Rate
tobacco metabolism
Title Single Nucleotide Polymorphisms in Tobacco Metabolism and DNA Repair Genes and Prognosis in Resected Non-Small-Cell Lung Cancer
URI https://www.clinicalkey.es/playcontent/1-s2.0-S0022480411000047
https://dx.doi.org/10.1016/j.jss.2011.01.007
https://www.ncbi.nlm.nih.gov/pubmed/21324488
Volume 167
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