The role of phosphorylcreatine and creatine in the regulation of mitochondrial respiration in human skeletal muscle

• Published in: The Journal of physiology Vol. 537; no. 3; pp. 971 - 978
• Main Authors: Walsh, B, Tonkonogi, M, Soderlund, K, Hultman, E, Saks, V, Sahlin, K
• Format: Journal Article
• Language: English
• Published: England The Physiological Society 15.12.2001; Wiley
• Subjects: Adenosine Diphosphate; Adenosine Diphosphate - pharmacology; Adult; Creatine; Creatine - pharmacology; Creatine - physiology; Exercise; Exercise - physiology; Humans; Male; Mitochondria, Muscle; Mitochondria, Muscle - metabolism; Muscle, Skeletal; Muscle, Skeletal - metabolism; Oxygen Consumption; Oxygen Consumption - drug effects; Oxygen Consumption - physiology; Phosphocreatine; Phosphocreatine - pharmacology; Phosphocreatine - physiology

The role of phosphorylcreatine (PCr) and creatine (Cr) in the regulation of mitochondrial respiration was investigated in permeabilised fibre bundles prepared from human vastus lateralis muscle. Fibre respiration was measured in the absence of ADP ( V̇ 0 ) and after sequential additions of submaxim...