The Role of Neoadjuvant Therapy to Improve the Extent of Resection in “Unresectable” Gliomas

• Published in: World neurosurgery Vol. 146; pp. 53 - 58
• Main Authors: Jacobo, Javier A., Mejia-Perez, Sonia, Moreno-Jimenez, Sergio
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2021
• Subjects: Chemotherapy; Glioma; Neoadjuvant; Resection; Temozolomide; TMZ; PCV; Resection; GTR; OS; MRI; IDH1; Neoadjuvant; EOR; HGG; LGG; Chemotherapy; Glioma; BV; Temozolomide; GB; PFS; PD-1; WHO

Surgical resection plays a pivotal role in the management of glial tumors and a greater extent of resection (EOR) should be the goal in most surgeries to improve overall survival. Many factors may limit the EOR. A potential role for preoperative chemotherapy to decrease the volume and/or infiltratio...