Real-World Outcomes with Chimeric Antigen Receptor T Cell Therapies in Large B Cell Lymphoma: A Systematic Review and Meta-Analysis

• Published in: Transplantation and cellular therapy Vol. 30; no. 1; pp. 77.e1 - 77.e15
• Main Authors: Jacobson, Caron A., Munoz, Javier, Sun, Fang, Kanters, Steve, Limbrick-Oldfield, Eve H., Spooner, Clare, Mignone, Krystal, Ayuk, Francis, Sanderson, Robin, Whitmore, James, Wang, Yuanyuan, Xu, Hairong, Dickinson, Michael
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2024
• Subjects: Axi-cel; CAR-T cell therapy; Cytokine Release Syndrome; Humans; Immunotherapy, Adoptive - adverse effects; LBCL; Lymphoma, Large B-Cell, Diffuse - therapy; Meta-analysis; Neurotoxicity Syndromes; Observational Studies as Topic; Pathologic Complete Response; Real-world evidence; Receptors, Chimeric Antigen - metabolism; Retrospective Studies; T-Lymphocytes; Tisa-cel; Tisa-cel; LBCL; CAR-T cell therapy; Axi-cel; Real-world evidence; Meta-analysis

•A rich body of real-world evidence has been developed for chimeric antigen receptor T cell (CAR-T) therapies in LBCL.•In the real world, CAR-T was used in a broader patient population than in trials.•Real-world CAR-T effectiveness and safety were comparable with trial results.•Axi-cel was associate...