A crosslinked polymer skin barrier film for moderate to severe atopic dermatitis: A pilot study in adults
Occlusive treatments are a mainstay in atopic dermatitis (AD) management but may not be well tolerated or lack compliance. A comfortable, semiocclusive, artificial skin barrier that is well tolerated, provides protection, and reduces water loss is needed. To evaluate the potential tolerability and t...
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| Published in | Journal of the American Academy of Dermatology Vol. 82; no. 4; pp. 895 - 901 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.04.2020
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| Subjects | |
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| Abstract | Occlusive treatments are a mainstay in atopic dermatitis (AD) management but may not be well tolerated or lack compliance. A comfortable, semiocclusive, artificial skin barrier that is well tolerated, provides protection, and reduces water loss is needed.
To evaluate the potential tolerability and therapeutic benefits of a crosslinked polymer layer (XPL) in adults with AD.
A single-center, open-label pilot study was conducted involving 10 subjects with moderate to severe AD. Subjects applied XPL up to twice daily for 30 days on a selected treatment area. Investigator's Global Assessment, clinical signs of eczema, and pruritus were assessed on days 1, 3, 5, 15, and 30. Film durability and patient satisfaction were also evaluated.
Investigator's Global Assessment scores improved from moderate to severe at baseline to clear to almost clear in 8 of 9 patients at day 30. Pruritus improved from trace to severe itching (baseline) to all subjects having trace to no itching at day 30. There was 1 adverse event of mild exudative dermatitis.
The study was limited by small sample size, open-label design, and lack of control.
XPL may be an effective adjuvant in AD treatment. A larger study with a control group is warranted. |
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| AbstractList | Occlusive treatments are a mainstay in atopic dermatitis (AD) management but may not be well tolerated or lack compliance. A comfortable, semiocclusive, artificial skin barrier that is well tolerated, provides protection, and reduces water loss is needed.
To evaluate the potential tolerability and therapeutic benefits of a crosslinked polymer layer (XPL) in adults with AD.
A single-center, open-label pilot study was conducted involving 10 subjects with moderate to severe AD. Subjects applied XPL up to twice daily for 30 days on a selected treatment area. Investigator's Global Assessment, clinical signs of eczema, and pruritus were assessed on days 1, 3, 5, 15, and 30. Film durability and patient satisfaction were also evaluated.
Investigator's Global Assessment scores improved from moderate to severe at baseline to clear to almost clear in 8 of 9 patients at day 30. Pruritus improved from trace to severe itching (baseline) to all subjects having trace to no itching at day 30. There was 1 adverse event of mild exudative dermatitis.
The study was limited by small sample size, open-label design, and lack of control.
XPL may be an effective adjuvant in AD treatment. A larger study with a control group is warranted. Occlusive treatments are a mainstay in atopic dermatitis (AD) management but may not be well tolerated or lack compliance. A comfortable, semiocclusive, artificial skin barrier that is well tolerated, provides protection, and reduces water loss is needed.BACKGROUNDOcclusive treatments are a mainstay in atopic dermatitis (AD) management but may not be well tolerated or lack compliance. A comfortable, semiocclusive, artificial skin barrier that is well tolerated, provides protection, and reduces water loss is needed.To evaluate the potential tolerability and therapeutic benefits of a crosslinked polymer layer (XPL) in adults with AD.OBJECTIVETo evaluate the potential tolerability and therapeutic benefits of a crosslinked polymer layer (XPL) in adults with AD.A single-center, open-label pilot study was conducted involving 10 subjects with moderate to severe AD. Subjects applied XPL up to twice daily for 30 days on a selected treatment area. Investigator's Global Assessment, clinical signs of eczema, and pruritus were assessed on days 1, 3, 5, 15, and 30. Film durability and patient satisfaction were also evaluated.METHODSA single-center, open-label pilot study was conducted involving 10 subjects with moderate to severe AD. Subjects applied XPL up to twice daily for 30 days on a selected treatment area. Investigator's Global Assessment, clinical signs of eczema, and pruritus were assessed on days 1, 3, 5, 15, and 30. Film durability and patient satisfaction were also evaluated.Investigator's Global Assessment scores improved from moderate to severe at baseline to clear to almost clear in 8 of 9 patients at day 30. Pruritus improved from trace to severe itching (baseline) to all subjects having trace to no itching at day 30. There was 1 adverse event of mild exudative dermatitis.RESULTSInvestigator's Global Assessment scores improved from moderate to severe at baseline to clear to almost clear in 8 of 9 patients at day 30. Pruritus improved from trace to severe itching (baseline) to all subjects having trace to no itching at day 30. There was 1 adverse event of mild exudative dermatitis.The study was limited by small sample size, open-label design, and lack of control.LIMITATIONSThe study was limited by small sample size, open-label design, and lack of control.XPL may be an effective adjuvant in AD treatment. A larger study with a control group is warranted.CONCLUSIONXPL may be an effective adjuvant in AD treatment. A larger study with a control group is warranted. |
| Author | Akthakul, Ariya Anderson, R. Rox Beccati, Daniela Sakamoto, Fernanda H. Nashat, Amir Ramadurai, Nithin Bouthillette, Melaney Langer, Robert |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31589946$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1111_dth_15884 crossref_primary_10_3390_pharmaceutics13070932 crossref_primary_10_3390_pharmaceutics13070999 crossref_primary_10_1111_srt_13149 crossref_primary_10_3390_pharmaceutics14061149 crossref_primary_10_1080_10255842_2024_2372621 crossref_primary_10_2174_1567201819666220307112525 crossref_primary_10_3390_pharmaceutics13030341 |
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| Keywords | itch BSA IGA skin barrier function AD XPL eczema atopic dermatitis inflammatory skin diseases silicone dressing |
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| SubjectTerms | atopic dermatitis eczema inflammatory skin diseases itch silicone dressing skin barrier function |
| Title | A crosslinked polymer skin barrier film for moderate to severe atopic dermatitis: A pilot study in adults |
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