NLRX1 Protein Attenuates Inflammatory Responses to Infection by Interfering with the RIG-I-MAVS and TRAF6-NF-κB Signaling Pathways

• Published in: Immunity (Cambridge, Mass.) Vol. 34; no. 6; pp. 854 - 865
• Main Authors: Allen, Irving C., Moore, Chris B., Schneider, Monika, Lei, Yu, Davis, Beckley K., Scull, Margaret A., Gris, Denis, Roney, Kelly E., Zimmermann, Albert G., Bowzard, John B., Ranjan, Priya, Monroe, Kathryn M., Pickles, Raymond J., Sambhara, Suryaprakash, Ting, Jenny P.Y.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 24.06.2011
• Subjects: Adaptor Proteins, Signal Transducing - immunology; Adaptor Proteins, Signal Transducing - metabolism; Animals; Cells, Cultured; Influenza A Virus, H1N1 Subtype - immunology; Interferon-beta - biosynthesis; Interferon-beta - immunology; Interleukin-6 - biosynthesis; Interleukin-6 - immunology; Macrophages - immunology; Membrane Proteins - immunology; Membrane Proteins - metabolism; Mice; Mice, Knockout; Mitochondrial Proteins - deficiency; Mitochondrial Proteins - immunology; Nerve Tissue Proteins - immunology; Nerve Tissue Proteins - metabolism; NF-kappa B - immunology; NF-kappa B - metabolism; Orthomyxoviridae Infections - immunology; Signal Transduction; TNF Receptor-Associated Factor 6 - immunology; TNF Receptor-Associated Factor 6 - metabolism

The nucleotide-binding domain and leucine-rich-repeat-containing (NLR) proteins regulate innate immunity. Although the positive regulatory impact of NLRs is clear, their inhibitory roles are not well defined. We showed that Nlrx1 −/− mice exhibited increased expression of antiviral signaling molecul...