Innovation in oncology clinical trial design

• Published in: Cancer treatment reviews Vol. 74; pp. 15 - 20
• Main Authors: Verweij, J., Hendriks, H.R., Zwierzina, H., Hanauske, Wacheck, V., Collignon, O., Bruzzi, P., Gross, J., Riehl, T., Bretz, F., Dollins, Radtke, I.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.03.2019
• Subjects: Drug development; Drug regulation; Estimand framework; Innovative clinical trial design; Oncology; Precision medicine; Estimand framework; Oncology; Precision medicine; Drug development; Drug regulation; Innovative clinical trial design

•Standard Phase III trials are not always suited to assess new targeted oncology drugs.•Innovative trial designs and alternative regulatory pathways are therefore needed.•Enabling patients earlier potential benefit from rapid access to these novel drugs. Progress in and better understanding of cance...