Challenges in the Development of Biological Approaches for the Treatment of Degenerative Disc Disease

• Published in: World neurosurgery Vol. 157; pp. 274 - 281
• Main Authors: Goldberg, Jacob L., Garton, Andrew, Singh, Sunidhi, Kirnaz, Sertac, Sommer, Fabian, Carnevale, Joseph A., Atalay, Basar, Medary, Branden, McGrath, Lynn B., Härtl, Roger
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2022
• Subjects: Animals; Biological disc replacement challenges; Biological Factors - physiology; Biological Products - pharmacology; Biological Products - therapeutic use; Biomechanical Phenomena - physiology; Degenerative disc disease; Extracellular Matrix - drug effects; Extracellular Matrix - physiology; Humans; Intervertebral Disc Degeneration - diagnostic imaging; Intervertebral Disc Degeneration - physiopathology; Intervertebral Disc Degeneration - therapy; Intervertebral disc replacement obstacles; Magnetic Resonance Imaging - methods; Biological disc replacement challenges; DDD; MRI; Intervertebral disc replacement obstacles; IVD; Degenerative disc disease

There are numerous innovative and promising approaches aimed at slowing, reversing, or healing degenerative disc disease. However, multiple treatment-specific impediments slow progress toward realizing the benefits of these therapies. First, the exact pathophysiology underlying degenerative disc dis...