Challenges in the Development of Biological Approaches for the Treatment of Degenerative Disc Disease
There are numerous innovative and promising approaches aimed at slowing, reversing, or healing degenerative disc disease. However, multiple treatment-specific impediments slow progress toward realizing the benefits of these therapies. First, the exact pathophysiology underlying degenerative disc dis...
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| Published in | World neurosurgery Vol. 157; pp. 274 - 281 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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United States
Elsevier Inc
01.01.2022
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| Abstract | There are numerous innovative and promising approaches aimed at slowing, reversing, or healing degenerative disc disease. However, multiple treatment-specific impediments slow progress toward realizing the benefits of these therapies. First, the exact pathophysiology underlying degenerative disc disease remains complicated and challenging to study. In addition, the study of the spine and intervertebral disc in animal models is difficult to translate to humans, hindering the utility of preclinical research. Biological treatments are subject to the complex biomechanical environment in which native discs degenerate. The regulatory approval environment for these therapeutics will likely involve a high degree of scrutiny. Finally, patient selection and assessment of outcomes are a particular challenge in this clinical setting. |
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| AbstractList | There are numerous innovative and promising approaches aimed at slowing, reversing, or healing degenerative disc disease. However, multiple treatment-specific impediments slow progress toward realizing the benefits of these therapies. First, the exact pathophysiology underlying degenerative disc disease remains complicated and challenging to study. In addition, the study of the spine and intervertebral disc in animal models is difficult to translate to humans, hindering the utility of preclinical research. Biological treatments are subject to the complex biomechanical environment in which native discs degenerate. The regulatory approval environment for these therapeutics will likely involve a high degree of scrutiny. Finally, patient selection and assessment of outcomes are a particular challenge in this clinical setting. There are numerous innovative and promising approaches aimed at slowing, reversing, or healing degenerative disc disease. However, multiple treatment-specific impediments slow progress toward realizing the benefits of these therapies. First, the exact pathophysiology underlying degenerative disc disease remains complicated and challenging to study. In addition, the study of the spine and intervertebral disc in animal models is difficult to translate to humans, hindering the utility of preclinical research. Biological treatments are subject to the complex biomechanical environment in which native discs degenerate. The regulatory approval environment for these therapeutics will likely involve a high degree of scrutiny. Finally, patient selection and assessment of outcomes are a particular challenge in this clinical setting.There are numerous innovative and promising approaches aimed at slowing, reversing, or healing degenerative disc disease. However, multiple treatment-specific impediments slow progress toward realizing the benefits of these therapies. First, the exact pathophysiology underlying degenerative disc disease remains complicated and challenging to study. In addition, the study of the spine and intervertebral disc in animal models is difficult to translate to humans, hindering the utility of preclinical research. Biological treatments are subject to the complex biomechanical environment in which native discs degenerate. The regulatory approval environment for these therapeutics will likely involve a high degree of scrutiny. Finally, patient selection and assessment of outcomes are a particular challenge in this clinical setting. |
| Author | Carnevale, Joseph A. Goldberg, Jacob L. Singh, Sunidhi Medary, Branden Garton, Andrew Härtl, Roger Kirnaz, Sertac Atalay, Basar Sommer, Fabian McGrath, Lynn B. |
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| Cites_doi | 10.1097/00007632-200201150-00002 10.1016/j.jocn.2020.05.040 10.1016/j.spinee.2013.01.041 10.1016/j.pmrj.2011.04.020 10.1007/s00586-011-1916-1 10.1038/nrrheum.2013.160 10.1097/00007632-200108150-00003 10.1055/s-0030-1267084 10.1371/journal.pone.0185716 10.1055/s-0028-1100918 10.1016/j.spinee.2014.04.017 10.1093/neuros/nyx048 10.22203/eCM.v027sa02 10.1097/00007632-198802000-00008 10.1097/BRS.0000000000000194 10.1186/ar3548 10.1016/j.actbio.2018.07.008 10.22203/eCM.v026a01 10.1186/ar1732 10.1056/NEJMoa1912658 10.1097/01.brs.0000231761.73859.2c 10.1007/s005860100346 10.1097/00007632-199608010-00011 10.1126/scitranslmed.aay2380 10.2519/jospt.2001.31.6.291 10.1523/JNEUROSCI.20-16-06289.2000 10.1097/01.brs.0000158954.68522.2a 10.1007/s00586-013-3142-5 10.3171/2013.12.SPINE13112 10.1089/ten.tea.2009.0250 10.1038/s41584-019-0159-0 10.1186/scrt18 10.1371/journal.pone.0069610 10.1016/j.joca.2013.10.019 10.1097/BRS.0b013e3182608ac4 10.1038/nrrheum.2015.13 10.1097/BRS.0b013e3181ec5c7d 10.1007/s00701-009-0217-5 10.1136/annrheumdis-2012-201551 10.22203/eCM.v030a10 10.1073/pnas.1107094108 10.1097/00003086-197711000-00015 10.1097/00007632-199804010-00001 10.1016/j.joca.2011.04.005 10.1001/jama.296.20.2441 10.1016/j.copbio.2013.04.012 10.1097/00007632-198203000-00002 10.3233/BIR-2008-0498 10.1089/ten.teb.2017.0351 10.1055/s-0036-1571955 10.1097/00007632-199104000-00010 10.1097/01.brs.0000154619.38122.47 |
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| Keywords | Biological disc replacement challenges DDD MRI Intervertebral disc replacement obstacles IVD Degenerative disc disease |
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| References | Sloan, Lintz, Hussain, Hartl, Bonassar (bib55) 2018; 24 Atlas, Deyo, Keller (bib11) 1996; 21 Hudson, Alimi, Grunert, Härtl, Bonassar (bib54) 2013; 24 Grunert, Hudson, Macielak (bib52) 2014; 39 Miyazaki, Kobayashi, Takeno, Meir, Urban, Baba (bib36) 2009; 15 Gebhard, Bowles, Dyke (bib26) 2010; 1 Smit (bib22) 2002; 11 Benneker, Andersson, Iatridis (bib57) 2014; 27 Moriguchi, Alimi, Khair (bib24) 2016; 6 Moriguchi, Mojica-Santiago, Grunert (bib37) 2017; 12 Atlas, Keller, Wu, Deyo, Singer (bib10) 2005; 30 Larson, Levicoff, Gilbertson, Kang (bib45) 2006; 88 Weinstein, Tosteson, Lurie (bib13) 2006; 296 Sugawara, Itoh, Hirano, Higashiyama, Mizoi (bib5) 2009; 151 (bib50) 2004; 69 Gebhard, James, Bowles (bib27) 2011; 2 Grunert, Gebhard, Bowles (bib53) 2014; 20 Stairmand, Holm, Urban (bib31) 1991; 16 Akeson, Woo, Taylor, Ghosh, Bushell (bib29) 1977; 129 Miller, Schmatz, Schultz (bib2) 1988; 13 Pennicooke, Moriguchi, Hussain, Bonssar, Härtl (bib7) 2016; 8 Garcia, Histing, Holstein (bib32) 2013; 26 Moriguchi, Borde, Berlin (bib56) 2018; 79 McHugh (bib6) 2019; 15 Santillan, Goldberg, Carnevale, Kirnaz, Hartl, Knopman (bib9) 2020; 77 Williams, Bansal, van Meurs (bib16) 2013; 72 Mayer, Iatridis, Chan, Qureshi, Gottesman, Hecht (bib17) 2013; 13 Teraguchi, Yoshimura, Hashizume (bib1) 2014; 22 Wang, Baer, Kraus, Setton (bib44) 2001; 26 Reitmaier, Schmidt, Ihler (bib23) 2013; 8 Bibby, Jones, Ripley, Urban (bib43) 2005; 30 Motaghinasab, Shirazi-Adl, Parnianpour, Urban (bib30) 2014; 23 Ament, Mollan, Greenan, Binyamin, Kim (bib51) 2017; 80 Oprée, Kress (bib19) 2000; 20 Kelly, Mok, Frisch, Tay (bib4) 2011; 36 Zhang, Chee, Thonar, An (bib39) 2011; 3 Bowles, Gebhard, Härtl, Bonassar (bib25) 2011; 108 Erwin, Islam, Inman, Fehlings, Tsui (bib34) 2011; 13 Gruber, Hanley (bib47) 1998; 23 Bach, de Vries, Krouwels (bib33) 2015; 30 Bernick, Cailliet (bib20) 1982; 7 Maldonado, Paz, Martin (bib3) 2011; 20 Sloan, Wipplinger, Kirnaz (bib38) 2020; 12 Lundon, Bolton (bib28) 2001; 31 Korecki, Taboas, Tuan, Iatridis (bib35) 2010; 1 Sakai, Andersson (bib48) 2015; 11 Elfering, Semmer, Birkhofer, Zanetti, Hodler, Boos (bib8) 2002; 27 Adams, Roughley (bib15) 2006; 31 Illien-Jünger, Lu, Purmessur (bib40) 2014; 14 Bailey, Rasoulinejad, Taylor (bib12) 2020; 382 Wang, Videman, Battié (bib14) 2012; 37 Risbud, Shapiro (bib18) 2014; 10 Denayer, Stöhr, Van Roy (bib21) 2014; 2 Walter, Korecki, Purmessur, Roughley, Michalek, Iatridis (bib42) 2011; 19 Food and Drug Administration (bib49) 2004; 69 Le Maitre, Freemont, Hoyland (bib41) 2005; 7 Le Maitre, Frain, Fotheringham, Freemont, Hoyland (bib46) 2008; 45 Grunert (10.1016/j.wneu.2021.09.067_bib53) 2014; 20 Denayer (10.1016/j.wneu.2021.09.067_bib21) 2014; 2 Gruber (10.1016/j.wneu.2021.09.067_bib47) 1998; 23 Maldonado (10.1016/j.wneu.2021.09.067_bib3) 2011; 20 Atlas (10.1016/j.wneu.2021.09.067_bib11) 1996; 21 Bach (10.1016/j.wneu.2021.09.067_bib33) 2015; 30 Reitmaier (10.1016/j.wneu.2021.09.067_bib23) 2013; 8 (10.1016/j.wneu.2021.09.067_bib50) 2004; 69 McHugh (10.1016/j.wneu.2021.09.067_bib6) 2019; 15 Food and Drug Administration (10.1016/j.wneu.2021.09.067_bib49) 2004; 69 Smit (10.1016/j.wneu.2021.09.067_bib22) 2002; 11 Akeson (10.1016/j.wneu.2021.09.067_bib29) 1977; 129 Gebhard (10.1016/j.wneu.2021.09.067_bib26) 2010; 1 Miller (10.1016/j.wneu.2021.09.067_bib2) 1988; 13 Le Maitre (10.1016/j.wneu.2021.09.067_bib46) 2008; 45 Benneker (10.1016/j.wneu.2021.09.067_bib57) 2014; 27 Adams (10.1016/j.wneu.2021.09.067_bib15) 2006; 31 Garcia (10.1016/j.wneu.2021.09.067_bib32) 2013; 26 Sloan (10.1016/j.wneu.2021.09.067_bib38) 2020; 12 Teraguchi (10.1016/j.wneu.2021.09.067_bib1) 2014; 22 Illien-Jünger (10.1016/j.wneu.2021.09.067_bib40) 2014; 14 Larson (10.1016/j.wneu.2021.09.067_bib45) 2006; 88 Moriguchi (10.1016/j.wneu.2021.09.067_bib24) 2016; 6 Pennicooke (10.1016/j.wneu.2021.09.067_bib7) 2016; 8 Wang (10.1016/j.wneu.2021.09.067_bib14) 2012; 37 Moriguchi (10.1016/j.wneu.2021.09.067_bib56) 2018; 79 Weinstein (10.1016/j.wneu.2021.09.067_bib13) 2006; 296 Williams (10.1016/j.wneu.2021.09.067_bib16) 2013; 72 Oprée (10.1016/j.wneu.2021.09.067_bib19) 2000; 20 Le Maitre (10.1016/j.wneu.2021.09.067_bib41) 2005; 7 Motaghinasab (10.1016/j.wneu.2021.09.067_bib30) 2014; 23 Wang (10.1016/j.wneu.2021.09.067_bib44) 2001; 26 Zhang (10.1016/j.wneu.2021.09.067_bib39) 2011; 3 Sloan (10.1016/j.wneu.2021.09.067_bib55) 2018; 24 Bowles (10.1016/j.wneu.2021.09.067_bib25) 2011; 108 Kelly (10.1016/j.wneu.2021.09.067_bib4) 2011; 36 Grunert (10.1016/j.wneu.2021.09.067_bib52) 2014; 39 Elfering (10.1016/j.wneu.2021.09.067_bib8) 2002; 27 Sugawara (10.1016/j.wneu.2021.09.067_bib5) 2009; 151 Lundon (10.1016/j.wneu.2021.09.067_bib28) 2001; 31 Risbud (10.1016/j.wneu.2021.09.067_bib18) 2014; 10 Ament (10.1016/j.wneu.2021.09.067_bib51) 2017; 80 Bibby (10.1016/j.wneu.2021.09.067_bib43) 2005; 30 Walter (10.1016/j.wneu.2021.09.067_bib42) 2011; 19 Erwin (10.1016/j.wneu.2021.09.067_bib34) 2011; 13 Santillan (10.1016/j.wneu.2021.09.067_bib9) 2020; 77 Atlas (10.1016/j.wneu.2021.09.067_bib10) 2005; 30 Hudson (10.1016/j.wneu.2021.09.067_bib54) 2013; 24 Gebhard (10.1016/j.wneu.2021.09.067_bib27) 2011; 2 Mayer (10.1016/j.wneu.2021.09.067_bib17) 2013; 13 Korecki (10.1016/j.wneu.2021.09.067_bib35) 2010; 1 Bailey (10.1016/j.wneu.2021.09.067_bib12) 2020; 382 Miyazaki (10.1016/j.wneu.2021.09.067_bib36) 2009; 15 Stairmand (10.1016/j.wneu.2021.09.067_bib31) 1991; 16 Bernick (10.1016/j.wneu.2021.09.067_bib20) 1982; 7 Sakai (10.1016/j.wneu.2021.09.067_bib48) 2015; 11 Moriguchi (10.1016/j.wneu.2021.09.067_bib37) 2017; 12 |
| References_xml | – volume: 15 start-page: 66 year: 2019 ident: bib6 article-title: Moving towards tissue-engineered disc replacement publication-title: Nat Rev Rheumatol – volume: 26 start-page: 1747 year: 2001 end-page: 1751 ident: bib44 article-title: Intervertebral disc cells exhibit differences in gene expression in alginate and monolayer culture publication-title: Spine (Phila Pa 1976) – volume: 382 start-page: 1093 year: 2020 end-page: 1102 ident: bib12 article-title: Surgery versus conservative care for persistent sciatica lasting 4 to 12 months publication-title: N Engl J Med – volume: 22 start-page: 104 year: 2014 end-page: 110 ident: bib1 article-title: Prevalence and distribution of intervertebral disc degeneration over the entire spine in a population-based cohort: the Wakayama Spine Study publication-title: Osteoarthritis Cartilage – volume: 13 start-page: R215 year: 2011 ident: bib34 article-title: Notochordal cells protect nucleus pulposus cells from degradation and apoptosis: implications for the mechanisms of intervertebral disc degeneration publication-title: Arthritis Res Ther – volume: 79 start-page: 230 year: 2018 end-page: 238 ident: bib56 article-title: In vivo annular repair using high-density collagen gel seeded with annulus fibrosus cells publication-title: Acta Biomater – volume: 108 start-page: 13106 year: 2011 end-page: 13111 ident: bib25 article-title: Tissue-engineered intervertebral discs produce new matrix, maintain disc height, and restore biomechanical function to the rodent spine publication-title: Proc Natl Acad Sci U S A – volume: 27 start-page: 125 year: 2002 end-page: 134 ident: bib8 article-title: Risk factors for lumbar disc degeneration: a 5-year prospective MRI study in asymptomatic individuals publication-title: Spine (Phila Pa 1976) – volume: 27 start-page: 5 year: 2014 end-page: 11 ident: bib57 article-title: Cell therapy for intervertebral disc repair: advancing cell therapy from bench to clinics publication-title: Eur Cell Mater – volume: 11 start-page: 137 year: 2002 end-page: 144 ident: bib22 article-title: The use of a quadruped as an in vivo model for the study of the spine—biomechanical considerations publication-title: Eur Spine J – volume: 21 start-page: 1777 year: 1996 end-page: 1786 ident: bib11 article-title: The Maine Lumbar Spine Study, Part II: 1-year outcomes of surgical and nonsurgical management of sciatica publication-title: Spine (Phila Pa 1976) – volume: 296 start-page: 2441 year: 2006 end-page: 2450 ident: bib13 article-title: Surgical vs nonoperative treatment for lumbar disk herniation: the Spine Patient Outcomes Research Trial (SPORT): a randomized trial publication-title: JAMA – volume: 12 start-page: e0185716 year: 2017 ident: bib37 article-title: Total disc replacement using tissue-engineered intervertebral discs in the canine cervical spine publication-title: PLoS One – volume: 69 start-page: 29785 year: 2004 end-page: 29834 ident: bib49 article-title: Eligibility determination for donors of human cells, tissues, and cellular and tissue-based products. Final rule publication-title: Fed Regist – volume: 80 start-page: 840 year: 2017 end-page: 846 ident: bib51 article-title: Understanding United States Investigational Device Exemption studies—clinical relevance and importance for healthcare economics publication-title: Neurosurgery – volume: 14 start-page: 2724 year: 2014 end-page: 2732 ident: bib40 article-title: Detrimental effects of discectomy on intervertebral disc biology can be decelerated by growth factor treatment during surgery: a large animal organ culture model publication-title: Spine J – volume: 23 start-page: 715 year: 2014 end-page: 723 ident: bib30 article-title: Disc size markedly influences concentration profiles of intravenously administered solutes in the intervertebral disc: a computational study on glucosamine as a model solute publication-title: Eur Spine J – volume: 31 start-page: 2151 year: 2006 end-page: 2161 ident: bib15 article-title: What is intervertebral disc degeneration, and what causes it? publication-title: Spine (Phila Pa 1976) – volume: 77 start-page: 211 year: 2020 end-page: 212 ident: bib9 article-title: Anterior spinal artery syndrome caused by thoracic disc herniation publication-title: J Clin Neurosci – volume: 13 start-page: 299 year: 2013 end-page: 317 ident: bib17 article-title: Genetic polymorphisms associated with intervertebral disc degeneration publication-title: Spine J – volume: 37 start-page: 1490 year: 2012 end-page: 1496 ident: bib14 article-title: ISSLS prize winner: Lumbar vertebral endplate lesions: associations with disc degeneration and back pain history publication-title: Spine (Phila Pa 1976) – volume: 2 start-page: 5 year: 2014 end-page: 11 ident: bib21 article-title: Animal models in translational medicine: validation and prediction publication-title: New Horizons in Translational Medicine – volume: 20 start-page: 443 year: 2014 end-page: 451 ident: bib53 article-title: Tissue-engineered intervertebral discs: MRI results and histology in the rodent spine publication-title: J Neurosurg Spine – volume: 129 start-page: 133 year: 1977 end-page: 140 ident: bib29 article-title: Biomechanics and biochemistry of the intervertebral disks: the need for correlation studies publication-title: Clin Orthop Relat Res – volume: 8 start-page: e69610 year: 2013 ident: bib23 article-title: Preliminary investigations on intradiscal pressures during daily activities: an in vivo study using the merino sheep publication-title: PLoS One – volume: 69 start-page: 68611 year: 2004 end-page: 68688 ident: bib50 article-title: Current good tissue practice for human cell, tissue, and cellular and tissue-based product establishments; inspection and enforcement. Final rule publication-title: Fed Regist – volume: 16 start-page: 444 year: 1991 end-page: 449 ident: bib31 article-title: Factors influencing oxygen concentration gradients in the intervertebral disc. A theoretical analysis publication-title: Spine (Phila Pa 1976) – volume: 39 start-page: E369 year: 2014 end-page: E378 ident: bib52 article-title: Assessment of intervertebral disc degeneration based on quantitative magnetic resonance imaging analysis: an in vivo study publication-title: Spine (Phila Pa 1976) – volume: 2 start-page: 29 year: 2011 end-page: 35 ident: bib27 article-title: Biological intervertebral disc replacement: an in vivo model and comparison of two surgical techniques to approach the rat caudal disc publication-title: Evid Based Spine Care J – volume: 1 start-page: 18 year: 2010 ident: bib35 article-title: Notochordal cell conditioned medium stimulates mesenchymal stem cell differentiation toward a young nucleus pulposus phenotype publication-title: Stem Cell Res Ther – volume: 88 start-page: 83 year: 2006 end-page: 87 ident: bib45 article-title: Biologic modification of animal models of intervertebral disc degeneration publication-title: J Bone Joint Surg Am – volume: 72 start-page: 1141 year: 2013 end-page: 1148 ident: bib16 article-title: Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects publication-title: Ann Rheum Dis – volume: 12 start-page: eaay2380 year: 2020 ident: bib38 article-title: Combined nucleus pulposus augmentation and annulus fibrosus repair prevents acute intervertebral disc degeneration after discectomy publication-title: Sci Transl Med – volume: 11 start-page: 243 year: 2015 end-page: 256 ident: bib48 article-title: Stem cell therapy for intervertebral disc regeneration: obstacles and solutions publication-title: Nat Rev Rheumatol – volume: 151 start-page: 303 year: 2009 end-page: 309 ident: bib5 article-title: Long term outcome and adjacent disc degeneration after anterior cervical discectomy and fusion with titanium cylindrical cages publication-title: Acta Neurochir (Wien) – volume: 6 start-page: 497 year: 2016 end-page: 518 ident: bib24 article-title: Biological treatment approaches for degenerative disk disease: a literature review of in vivo animal and clinical data publication-title: Global Spine J – volume: 7 start-page: R732 year: 2005 end-page: R745 ident: bib41 article-title: The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration publication-title: Arthritis Res Ther – volume: 36 start-page: 1171 year: 2011 end-page: 1179 ident: bib4 article-title: Adjacent segment motion after anterior cervical discectomy and fusion versus Prodisc-c cervical total disk arthroplasty: analysis from a randomized, controlled trial publication-title: Spine (Phila Pa 1976) – volume: 30 start-page: 487 year: 2005 end-page: 496 ident: bib43 article-title: Metabolism of the intervertebral disc: effects of low levels of oxygen, glucose, and pH on rates of energy metabolism of bovine nucleus pulposus cells publication-title: Spine (Phila Pa 1976) – volume: 24 start-page: 179 year: 2018 end-page: 190 ident: bib55 article-title: Biologic annulus fibrosus repair: A review of preclinical in vivo investigations publication-title: Tissue Eng Part B Rev – volume: 24 start-page: 872 year: 2013 end-page: 879 ident: bib54 article-title: Recent advances in biological therapies for disc degeneration: tissue engineering of the annulus fibrosus, nucleus pulposus and whole intervertebral discs publication-title: Curr Opin Biotechnol – volume: 26 start-page: 1 year: 2013 end-page: 12 ident: bib32 article-title: Rodent animal models of delayed bone healing and non-union formation: a comprehensive review publication-title: Eur Cell Mater – volume: 20 start-page: 403 year: 2011 end-page: 407 ident: bib3 article-title: Adjacent-level degeneration after cervical disc arthroplasty versus fusion publication-title: Eur Spine J – volume: 30 start-page: 927 year: 2005 end-page: 935 ident: bib10 article-title: Long-term outcomes of surgical and nonsurgical management of sciatica secondary to a lumbar disc herniation: 10 year results from the Maine Lumbar Spine Study publication-title: Spine (Phila Pa 1976) – volume: 10 start-page: 44 year: 2014 end-page: 56 ident: bib18 article-title: Role of cytokines in intervertebral disc degeneration: pain and disc content publication-title: Nat Rev Rheumatol – volume: 3 start-page: S88 year: 2011 end-page: S94 ident: bib39 article-title: Intervertebral disk repair by protein, gene, or cell injection: a framework for rehabilitation-focused biologics in the spine publication-title: PM R – volume: 19 start-page: 1011 year: 2011 end-page: 1018 ident: bib42 article-title: Complex loading affects intervertebral disc mechanics and biology publication-title: Osteoarthritis Cartilage – volume: 7 start-page: 97 year: 1982 end-page: 102 ident: bib20 article-title: Vertebral end-plate changes with aging of human vertebrae publication-title: Spine (Phila Pa 1976) – volume: 13 start-page: 173 year: 1988 end-page: 178 ident: bib2 article-title: Lumbar disc degeneration: correlation with age, sex, and spine level in 600 autopsy specimens publication-title: Spine (Phila Pa 1976) – volume: 15 start-page: 3835 year: 2009 end-page: 3846 ident: bib36 article-title: A phenotypic comparison of proteoglycan production of intervertebral disc cells isolated from rats, rabbits, and bovine tails; which animal model is most suitable to study tissue engineering and biological repair of human disc disorders? publication-title: Tissue Eng Part A – volume: 8 start-page: e892 year: 2016 ident: bib7 article-title: Biological treatment approaches for degenerative disc disease: A review of clinical trials and future directions publication-title: Cureus – volume: 31 start-page: 291 year: 2001 end-page: 303 ident: bib28 article-title: Structure and function of the lumbar intervertebral disk in health, aging, and pathologic conditions publication-title: J Orthop Sports Phys Ther – volume: 23 start-page: 751 year: 1998 end-page: 757 ident: bib47 article-title: Analysis of aging and degeneration of the human intervertebral disc. Comparison of surgical specimens with normal controls publication-title: Spine (Phila Pa 1976) – volume: 20 start-page: 6289 year: 2000 end-page: 6293 ident: bib19 article-title: Involvement of the proinflammatory cytokines tumor necrosis factor-alpha, IL-1 beta, and IL-6 but not IL-8 in the development of heat hyperalgesia: effects on heat-evoked calcitonin gene-related peptide release from rat skin publication-title: J Neurosci – volume: 1 start-page: 62 year: 2010 end-page: 66 ident: bib26 article-title: Total disc replacement using a tissue-engineered intervertebral disc in vivo: new animal model and initial results publication-title: Evid Based Spine Care J – volume: 45 start-page: 563 year: 2008 end-page: 575 ident: bib46 article-title: Human cells derived from degenerate intervertebral discs respond differently to those derived from non-degenerate intervertebral discs following application of dynamic hydrostatic pressure publication-title: Biorheology – volume: 30 start-page: 132 year: 2015 end-page: 146 ident: bib33 article-title: The species-specific regenerative effects of notochordal cell-conditioned medium on chondrocyte-like cells derived from degenerated human intervertebral discs publication-title: Eur Cell Mater – volume: 27 start-page: 125 year: 2002 ident: 10.1016/j.wneu.2021.09.067_bib8 article-title: Risk factors for lumbar disc degeneration: a 5-year prospective MRI study in asymptomatic individuals publication-title: Spine (Phila Pa 1976) doi: 10.1097/00007632-200201150-00002 – volume: 77 start-page: 211 year: 2020 ident: 10.1016/j.wneu.2021.09.067_bib9 article-title: Anterior spinal artery syndrome caused by thoracic disc herniation publication-title: J Clin Neurosci doi: 10.1016/j.jocn.2020.05.040 – volume: 13 start-page: 299 year: 2013 ident: 10.1016/j.wneu.2021.09.067_bib17 article-title: Genetic polymorphisms associated with intervertebral disc degeneration publication-title: Spine J doi: 10.1016/j.spinee.2013.01.041 – volume: 3 start-page: S88 issue: 6 Suppl 1 year: 2011 ident: 10.1016/j.wneu.2021.09.067_bib39 article-title: Intervertebral disk repair by protein, gene, or cell injection: a framework for rehabilitation-focused biologics in the spine publication-title: PM R doi: 10.1016/j.pmrj.2011.04.020 – volume: 20 start-page: 403 issue: Suppl 3 year: 2011 ident: 10.1016/j.wneu.2021.09.067_bib3 article-title: Adjacent-level degeneration after cervical disc arthroplasty versus fusion publication-title: Eur Spine J doi: 10.1007/s00586-011-1916-1 – volume: 10 start-page: 44 year: 2014 ident: 10.1016/j.wneu.2021.09.067_bib18 article-title: Role of cytokines in intervertebral disc degeneration: pain and disc content publication-title: Nat Rev Rheumatol doi: 10.1038/nrrheum.2013.160 – volume: 26 start-page: 1747 year: 2001 ident: 10.1016/j.wneu.2021.09.067_bib44 article-title: Intervertebral disc cells exhibit differences in gene expression in alginate and monolayer culture publication-title: Spine (Phila Pa 1976) doi: 10.1097/00007632-200108150-00003 – volume: 2 start-page: 29 year: 2011 ident: 10.1016/j.wneu.2021.09.067_bib27 article-title: Biological intervertebral disc replacement: an in vivo model and comparison of two surgical techniques to approach the rat caudal disc publication-title: Evid Based Spine Care J doi: 10.1055/s-0030-1267084 – volume: 12 start-page: e0185716 year: 2017 ident: 10.1016/j.wneu.2021.09.067_bib37 article-title: Total disc replacement using tissue-engineered intervertebral discs in the canine cervical spine publication-title: PLoS One doi: 10.1371/journal.pone.0185716 – volume: 1 start-page: 62 year: 2010 ident: 10.1016/j.wneu.2021.09.067_bib26 article-title: Total disc replacement using a tissue-engineered intervertebral disc in vivo: new animal model and initial results publication-title: Evid Based Spine Care J doi: 10.1055/s-0028-1100918 – volume: 14 start-page: 2724 year: 2014 ident: 10.1016/j.wneu.2021.09.067_bib40 article-title: Detrimental effects of discectomy on intervertebral disc biology can be decelerated by growth factor treatment during surgery: a large animal organ culture model publication-title: Spine J doi: 10.1016/j.spinee.2014.04.017 – volume: 80 start-page: 840 year: 2017 ident: 10.1016/j.wneu.2021.09.067_bib51 article-title: Understanding United States Investigational Device Exemption studies—clinical relevance and importance for healthcare economics publication-title: Neurosurgery doi: 10.1093/neuros/nyx048 – volume: 27 start-page: 5 year: 2014 ident: 10.1016/j.wneu.2021.09.067_bib57 article-title: Cell therapy for intervertebral disc repair: advancing cell therapy from bench to clinics publication-title: Eur Cell Mater doi: 10.22203/eCM.v027sa02 – volume: 13 start-page: 173 year: 1988 ident: 10.1016/j.wneu.2021.09.067_bib2 article-title: Lumbar disc degeneration: correlation with age, sex, and spine level in 600 autopsy specimens publication-title: Spine (Phila Pa 1976) doi: 10.1097/00007632-198802000-00008 – volume: 39 start-page: E369 year: 2014 ident: 10.1016/j.wneu.2021.09.067_bib52 article-title: Assessment of intervertebral disc degeneration based on quantitative magnetic resonance imaging analysis: an in vivo study publication-title: Spine (Phila Pa 1976) doi: 10.1097/BRS.0000000000000194 – volume: 13 start-page: R215 year: 2011 ident: 10.1016/j.wneu.2021.09.067_bib34 article-title: Notochordal cells protect nucleus pulposus cells from degradation and apoptosis: implications for the mechanisms of intervertebral disc degeneration publication-title: Arthritis Res Ther doi: 10.1186/ar3548 – volume: 69 start-page: 29785 year: 2004 ident: 10.1016/j.wneu.2021.09.067_bib49 article-title: Eligibility determination for donors of human cells, tissues, and cellular and tissue-based products. Final rule publication-title: Fed Regist – volume: 79 start-page: 230 year: 2018 ident: 10.1016/j.wneu.2021.09.067_bib56 article-title: In vivo annular repair using high-density collagen gel seeded with annulus fibrosus cells publication-title: Acta Biomater doi: 10.1016/j.actbio.2018.07.008 – volume: 26 start-page: 1 year: 2013 ident: 10.1016/j.wneu.2021.09.067_bib32 article-title: Rodent animal models of delayed bone healing and non-union formation: a comprehensive review publication-title: Eur Cell Mater doi: 10.22203/eCM.v026a01 – volume: 7 start-page: R732 year: 2005 ident: 10.1016/j.wneu.2021.09.067_bib41 article-title: The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration publication-title: Arthritis Res Ther doi: 10.1186/ar1732 – volume: 382 start-page: 1093 year: 2020 ident: 10.1016/j.wneu.2021.09.067_bib12 article-title: Surgery versus conservative care for persistent sciatica lasting 4 to 12 months publication-title: N Engl J Med doi: 10.1056/NEJMoa1912658 – volume: 31 start-page: 2151 year: 2006 ident: 10.1016/j.wneu.2021.09.067_bib15 article-title: What is intervertebral disc degeneration, and what causes it? publication-title: Spine (Phila Pa 1976) doi: 10.1097/01.brs.0000231761.73859.2c – volume: 11 start-page: 137 year: 2002 ident: 10.1016/j.wneu.2021.09.067_bib22 article-title: The use of a quadruped as an in vivo model for the study of the spine—biomechanical considerations publication-title: Eur Spine J doi: 10.1007/s005860100346 – volume: 21 start-page: 1777 year: 1996 ident: 10.1016/j.wneu.2021.09.067_bib11 article-title: The Maine Lumbar Spine Study, Part II: 1-year outcomes of surgical and nonsurgical management of sciatica publication-title: Spine (Phila Pa 1976) doi: 10.1097/00007632-199608010-00011 – volume: 12 start-page: eaay2380 year: 2020 ident: 10.1016/j.wneu.2021.09.067_bib38 article-title: Combined nucleus pulposus augmentation and annulus fibrosus repair prevents acute intervertebral disc degeneration after discectomy publication-title: Sci Transl Med doi: 10.1126/scitranslmed.aay2380 – volume: 31 start-page: 291 year: 2001 ident: 10.1016/j.wneu.2021.09.067_bib28 article-title: Structure and function of the lumbar intervertebral disk in health, aging, and pathologic conditions publication-title: J Orthop Sports Phys Ther doi: 10.2519/jospt.2001.31.6.291 – volume: 20 start-page: 6289 year: 2000 ident: 10.1016/j.wneu.2021.09.067_bib19 article-title: Involvement of the proinflammatory cytokines tumor necrosis factor-alpha, IL-1 beta, and IL-6 but not IL-8 in the development of heat hyperalgesia: effects on heat-evoked calcitonin gene-related peptide release from rat skin publication-title: J Neurosci doi: 10.1523/JNEUROSCI.20-16-06289.2000 – volume: 30 start-page: 927 year: 2005 ident: 10.1016/j.wneu.2021.09.067_bib10 article-title: Long-term outcomes of surgical and nonsurgical management of sciatica secondary to a lumbar disc herniation: 10 year results from the Maine Lumbar Spine Study publication-title: Spine (Phila Pa 1976) doi: 10.1097/01.brs.0000158954.68522.2a – volume: 69 start-page: 68611 year: 2004 ident: 10.1016/j.wneu.2021.09.067_bib50 article-title: Current good tissue practice for human cell, tissue, and cellular and tissue-based product establishments; inspection and enforcement. Final rule publication-title: Fed Regist – volume: 23 start-page: 715 year: 2014 ident: 10.1016/j.wneu.2021.09.067_bib30 article-title: Disc size markedly influences concentration profiles of intravenously administered solutes in the intervertebral disc: a computational study on glucosamine as a model solute publication-title: Eur Spine J doi: 10.1007/s00586-013-3142-5 – volume: 20 start-page: 443 year: 2014 ident: 10.1016/j.wneu.2021.09.067_bib53 article-title: Tissue-engineered intervertebral discs: MRI results and histology in the rodent spine publication-title: J Neurosurg Spine doi: 10.3171/2013.12.SPINE13112 – volume: 88 start-page: 83 issue: Suppl 2 year: 2006 ident: 10.1016/j.wneu.2021.09.067_bib45 article-title: Biologic modification of animal models of intervertebral disc degeneration publication-title: J Bone Joint Surg Am – volume: 15 start-page: 3835 year: 2009 ident: 10.1016/j.wneu.2021.09.067_bib36 article-title: A phenotypic comparison of proteoglycan production of intervertebral disc cells isolated from rats, rabbits, and bovine tails; which animal model is most suitable to study tissue engineering and biological repair of human disc disorders? publication-title: Tissue Eng Part A doi: 10.1089/ten.tea.2009.0250 – volume: 15 start-page: 66 year: 2019 ident: 10.1016/j.wneu.2021.09.067_bib6 article-title: Moving towards tissue-engineered disc replacement publication-title: Nat Rev Rheumatol doi: 10.1038/s41584-019-0159-0 – volume: 1 start-page: 18 year: 2010 ident: 10.1016/j.wneu.2021.09.067_bib35 article-title: Notochordal cell conditioned medium stimulates mesenchymal stem cell differentiation toward a young nucleus pulposus phenotype publication-title: Stem Cell Res Ther doi: 10.1186/scrt18 – volume: 8 start-page: e69610 year: 2013 ident: 10.1016/j.wneu.2021.09.067_bib23 article-title: Preliminary investigations on intradiscal pressures during daily activities: an in vivo study using the merino sheep publication-title: PLoS One doi: 10.1371/journal.pone.0069610 – volume: 22 start-page: 104 year: 2014 ident: 10.1016/j.wneu.2021.09.067_bib1 article-title: Prevalence and distribution of intervertebral disc degeneration over the entire spine in a population-based cohort: the Wakayama Spine Study publication-title: Osteoarthritis Cartilage doi: 10.1016/j.joca.2013.10.019 – volume: 37 start-page: 1490 year: 2012 ident: 10.1016/j.wneu.2021.09.067_bib14 article-title: ISSLS prize winner: Lumbar vertebral endplate lesions: associations with disc degeneration and back pain history publication-title: Spine (Phila Pa 1976) doi: 10.1097/BRS.0b013e3182608ac4 – volume: 11 start-page: 243 year: 2015 ident: 10.1016/j.wneu.2021.09.067_bib48 article-title: Stem cell therapy for intervertebral disc regeneration: obstacles and solutions publication-title: Nat Rev Rheumatol doi: 10.1038/nrrheum.2015.13 – volume: 36 start-page: 1171 year: 2011 ident: 10.1016/j.wneu.2021.09.067_bib4 article-title: Adjacent segment motion after anterior cervical discectomy and fusion versus Prodisc-c cervical total disk arthroplasty: analysis from a randomized, controlled trial publication-title: Spine (Phila Pa 1976) doi: 10.1097/BRS.0b013e3181ec5c7d – volume: 151 start-page: 303 year: 2009 ident: 10.1016/j.wneu.2021.09.067_bib5 article-title: Long term outcome and adjacent disc degeneration after anterior cervical discectomy and fusion with titanium cylindrical cages publication-title: Acta Neurochir (Wien) doi: 10.1007/s00701-009-0217-5 – volume: 2 start-page: 5 year: 2014 ident: 10.1016/j.wneu.2021.09.067_bib21 article-title: Animal models in translational medicine: validation and prediction publication-title: New Horizons in Translational Medicine – volume: 8 start-page: e892 year: 2016 ident: 10.1016/j.wneu.2021.09.067_bib7 article-title: Biological treatment approaches for degenerative disc disease: A review of clinical trials and future directions publication-title: Cureus – volume: 72 start-page: 1141 year: 2013 ident: 10.1016/j.wneu.2021.09.067_bib16 article-title: Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects publication-title: Ann Rheum Dis doi: 10.1136/annrheumdis-2012-201551 – volume: 30 start-page: 132 year: 2015 ident: 10.1016/j.wneu.2021.09.067_bib33 article-title: The species-specific regenerative effects of notochordal cell-conditioned medium on chondrocyte-like cells derived from degenerated human intervertebral discs publication-title: Eur Cell Mater doi: 10.22203/eCM.v030a10 – volume: 108 start-page: 13106 year: 2011 ident: 10.1016/j.wneu.2021.09.067_bib25 article-title: Tissue-engineered intervertebral discs produce new matrix, maintain disc height, and restore biomechanical function to the rodent spine publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1107094108 – volume: 129 start-page: 133 year: 1977 ident: 10.1016/j.wneu.2021.09.067_bib29 article-title: Biomechanics and biochemistry of the intervertebral disks: the need for correlation studies publication-title: Clin Orthop Relat Res doi: 10.1097/00003086-197711000-00015 – volume: 23 start-page: 751 year: 1998 ident: 10.1016/j.wneu.2021.09.067_bib47 article-title: Analysis of aging and degeneration of the human intervertebral disc. Comparison of surgical specimens with normal controls publication-title: Spine (Phila Pa 1976) doi: 10.1097/00007632-199804010-00001 – volume: 19 start-page: 1011 year: 2011 ident: 10.1016/j.wneu.2021.09.067_bib42 article-title: Complex loading affects intervertebral disc mechanics and biology publication-title: Osteoarthritis Cartilage doi: 10.1016/j.joca.2011.04.005 – volume: 296 start-page: 2441 year: 2006 ident: 10.1016/j.wneu.2021.09.067_bib13 article-title: Surgical vs nonoperative treatment for lumbar disk herniation: the Spine Patient Outcomes Research Trial (SPORT): a randomized trial publication-title: JAMA doi: 10.1001/jama.296.20.2441 – volume: 24 start-page: 872 year: 2013 ident: 10.1016/j.wneu.2021.09.067_bib54 article-title: Recent advances in biological therapies for disc degeneration: tissue engineering of the annulus fibrosus, nucleus pulposus and whole intervertebral discs publication-title: Curr Opin Biotechnol doi: 10.1016/j.copbio.2013.04.012 – volume: 7 start-page: 97 year: 1982 ident: 10.1016/j.wneu.2021.09.067_bib20 article-title: Vertebral end-plate changes with aging of human vertebrae publication-title: Spine (Phila Pa 1976) doi: 10.1097/00007632-198203000-00002 – volume: 45 start-page: 563 year: 2008 ident: 10.1016/j.wneu.2021.09.067_bib46 article-title: Human cells derived from degenerate intervertebral discs respond differently to those derived from non-degenerate intervertebral discs following application of dynamic hydrostatic pressure publication-title: Biorheology doi: 10.3233/BIR-2008-0498 – volume: 24 start-page: 179 year: 2018 ident: 10.1016/j.wneu.2021.09.067_bib55 article-title: Biologic annulus fibrosus repair: A review of preclinical in vivo investigations publication-title: Tissue Eng Part B Rev doi: 10.1089/ten.teb.2017.0351 – volume: 6 start-page: 497 year: 2016 ident: 10.1016/j.wneu.2021.09.067_bib24 article-title: Biological treatment approaches for degenerative disk disease: a literature review of in vivo animal and clinical data publication-title: Global Spine J doi: 10.1055/s-0036-1571955 – volume: 16 start-page: 444 year: 1991 ident: 10.1016/j.wneu.2021.09.067_bib31 article-title: Factors influencing oxygen concentration gradients in the intervertebral disc. A theoretical analysis publication-title: Spine (Phila Pa 1976) doi: 10.1097/00007632-199104000-00010 – volume: 30 start-page: 487 year: 2005 ident: 10.1016/j.wneu.2021.09.067_bib43 article-title: Metabolism of the intervertebral disc: effects of low levels of oxygen, glucose, and pH on rates of energy metabolism of bovine nucleus pulposus cells publication-title: Spine (Phila Pa 1976) doi: 10.1097/01.brs.0000154619.38122.47 |
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| SubjectTerms | Animals Biological disc replacement challenges Biological Factors - physiology Biological Products - pharmacology Biological Products - therapeutic use Biomechanical Phenomena - physiology Degenerative disc disease Extracellular Matrix - drug effects Extracellular Matrix - physiology Humans Intervertebral Disc Degeneration - diagnostic imaging Intervertebral Disc Degeneration - physiopathology Intervertebral Disc Degeneration - therapy Intervertebral disc replacement obstacles Magnetic Resonance Imaging - methods |
| Title | Challenges in the Development of Biological Approaches for the Treatment of Degenerative Disc Disease |
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