Resveratrol, sirtuins, and the promise of a DR mimetic

• Published in: Mechanisms of ageing and development Vol. 131; no. 4; pp. 261 - 269
• Main Author: Baur, Joseph A.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.04.2010
• Subjects: ADP Ribose Transferases - genetics; ADP Ribose Transferases - pharmacology; Animals; Diet; Diet, Reducing; Dietary restriction; Energy Metabolism - genetics; Humans; Longevity; Longevity - drug effects; Longevity - genetics; Longevity - physiology; Mimetic; Obesity - genetics; Primates - genetics; Primates - metabolism; Resveratrol; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - metabolism; Sirtuins; Sirtuins - drug effects; Sirtuins - genetics; Sirtuins - metabolism; Stilbenes; Sirtuins; Dietary restriction; Longevity; Mimetic; Resveratrol

Dietary restriction (DR) delays or prevents age-related diseases and extends lifespan in species ranging from yeast to primates. Although the applicability of this regimen to humans remains uncertain, a proportional response would add more healthy years to the average life than even a cure for cance...