80K-H Interacts with Inositol 1,4,5-Trisphosphate (IP3) Receptors and Regulates IP3-induced Calcium Release Activity

• Published in: The Journal of biological chemistry Vol. 284; no. 1; pp. 372 - 380
• Main Authors: Kawaai, Katsuhiro, Hisatsune, Chihiro, Kuroda, Yukiko, Mizutani, Akihiro, Tashiro, Tomoko, Mikoshiba, Katsuhiko
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 02.01.2009; American Society for Biochemistry and Molecular Biology
• Subjects: Adenosine Triphosphate - metabolism; Adenosylhomocysteinase - genetics; Adenosylhomocysteinase - metabolism; Animals; Calcium - metabolism; Calcium Channels - genetics; Calcium Channels - metabolism; Calcium Signaling - physiology; Calcium-Binding Proteins; Cerebellum - cytology; Cerebellum - metabolism; Chlorocebus aethiops; COS Cells; Cytochromes c - genetics; Cytochromes c - metabolism; Endoplasmic Reticulum - genetics; Endoplasmic Reticulum - metabolism; Glucosidases - genetics; Glucosidases - metabolism; Hippocampus - cytology; Hippocampus - metabolism; Humans; Huntingtin Protein; Inositol 1,4,5-Trisphosphate Receptors - genetics; Inositol 1,4,5-Trisphosphate Receptors - metabolism; Intracellular Signaling Peptides and Proteins - genetics; Intracellular Signaling Peptides and Proteins - metabolism; Lectins, C-Type - genetics; Lectins, C-Type - metabolism; Membrane Proteins - genetics; Membrane Proteins - metabolism; Mice; Mice, Inbred ICR; Microsomes - metabolism; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Neurons - cytology; Neurons - metabolism; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Receptors, Cytoplasmic and Nuclear - genetics; Receptors, Cytoplasmic and Nuclear - metabolism

Inositol 1,4,5-trisphosphate receptors (IP3Rs) are intracellular channel proteins that mediate calcium (Ca2+) release from the endoplasmic reticulum, and they are involved in many biological processes (e.g. fertilization, secretion, and synaptic plasticity). Recent reports show that IP3R activity is...