Mast cell TLR2 signaling is crucial for effective killing of Francisella tularensis

• Published in: The Journal of immunology (1950) Vol. 188; no. 11; pp. 5604 - 5611
• Main Authors: Rodriguez, Annette R, Yu, Jieh-Juen, Guentzel, M Neal, Navara, Christopher S, Klose, Karl E, Forsthuber, Thomas G, Chambers, James P, Berton, Michael T, Arulanandam, Bernard P
• Format: Journal Article
• Language: English
• Published: United States 01.06.2012
• Subjects: Animals; Cell Death - genetics; Cell Death - immunology; Francisella tularensis; Francisella tularensis - growth & development; Francisella tularensis - immunology; Interleukin-4 - deficiency; Mast Cells - immunology; Mast Cells - metabolism; Mast Cells - microbiology; Mice; Mice, Inbred C57BL; Mice, Knockout; Protein Transport - genetics; Protein Transport - immunology; Signal Transduction - genetics; Signal Transduction - immunology; Toll-Like Receptor 2 - deficiency; Toll-Like Receptor 2 - physiology; Toll-Like Receptor 4 - physiology; Tularemia - immunology; Tularemia - microbiology; Tularemia - prevention & control

TLR signaling is critical for early host defense against pathogens, but the contributions of mast cell TLR-mediated mechanisms and subsequent effector functions during pulmonary infection are largely unknown. We have previously demonstrated that mast cells, through the production of IL-4, effectivel...