High-fat diet promotes experimental colitis by inducing oxidative stress in the colon

• Published in: American journal of physiology: Gastrointestinal and liver physiology Vol. 317; no. 4; pp. G453 - G462
• Main Authors: Li, Xue, Wei, Xinzhi, Sun, Yue, Du, Jie, Li, Xin, Xun, Zhe, Li, Yan Chun
• Format: Journal Article
• Language: English
• Published: United States 01.10.2019
• Subjects: Animals; Cell Line; Cholesterol - blood; Cholesterol - metabolism; Colitis - chemically induced; Colitis - metabolism; Colitis - pathology; Colon - cytology; Colon - metabolism; Cytokines - metabolism; Diet, High-Fat - adverse effects; Epithelial Cells - metabolism; Fatty Acids, Nonesterified - blood; Fatty Acids, Nonesterified - metabolism; Humans; Intestinal Mucosa - metabolism; Male; Mice; Mice, Inbred C57BL; Myosin-Light-Chain Kinase - metabolism; Oxidative Stress; Reactive Oxygen Species - metabolism; Triglycerides - blood; Triglycerides - metabolism; Trinitrobenzenesulfonic Acid; intestinal epithelial barrier; colitis; oxidative stress; high-fat diet

Diets high in animal fats are associated with increased risks of inflammatory bowel disease, but the mechanism remains unclear. In this study, we investigated the effect of high-fat diet (HFD) on the development of experimental colitis in mice. Relative to mice fed low-fat diet (LFD), HFD feeding fo...