The circular RNA circ-ERBIN promotes growth and metastasis of colorectal cancer by miR-125a-5p and miR-138-5p/4EBP-1 mediated cap-independent HIF-1α translation

• Published in: Molecular cancer Vol. 19; no. 1; p. 1
• Main Authors: Chen, Liang-Yan, Wang, Lian, Ren, Yue-Xiang, Pang, Zheng, Liu, Yao, Sun, Xiao-Dong, Tu, Jian, Zhi, Zheng, Qin, Yan, Sun, Li-Na, Li, Jian-Ming
• Format: Journal Article
• Language: English
• Published: London BioMed Central 23.11.2020
• Subjects: Angiogenesis; Cancer; Cell growth; Cell proliferation; Circular RNA; Colorectal cancer; Colorectal carcinoma; Experiments; Fluorescence in situ hybridization; Gene expression; Hypoxia; Hypoxia-inducible factor 1a; Metastases; Metastasis; mRNA; Plasmids; Protein expression; Proteins; Translation; Tumors; Western blotting; China

Background Circular RNA (circRNAs) and hypoxia have been found to play the key roles in the pathogenesis and progression of cancer including colorectal cancer (CRC). However, the expressions and functions of the specific circRNAs in regulating hypoxia-involved CRC metastasis, and the circRNAs that a...