Human pancreatic afferent and efferent nerves: mapping and 3-D illustration of exocrine, endocrine, and adipose innervation

• Published in: American journal of physiology: Gastrointestinal and liver physiology Vol. 317; no. 5; pp. G694 - G706
• Main Authors: Chien, Hung-Jen, Chiang, Tsai-Chen, Peng, Shih-Jung, Chung, Mei-Hsin, Chou, Ya-Hsien, Lee, Chih-Yuan, Jeng, Yung-Ming, Tien, Yu-Wen, Tang, Shiue-Cheng
• Format: Journal Article
• Language: English
• Published: United States 01.11.2019
• Subjects: Acinar Cells - cytology; Adipose Tissue - cytology; Adipose Tissue - innervation; Adult; Animals; Female; Humans; Imaging, Three-Dimensional; Islets of Langerhans - cytology; Islets of Langerhans - innervation; Male; Mice; Mice, Inbred C57BL; Middle Aged; Neuroanatomical Tract-Tracing Techniques; Neurons, Afferent - cytology; Neurons, Afferent - metabolism; Neurons, Efferent - cytology; Neurons, Efferent - metabolism; Pancreas, Exocrine - cytology; Pancreas, Exocrine - innervation; Substance P - genetics; Substance P - metabolism; Tyrosine 3-Monooxygenase - genetics; Tyrosine 3-Monooxygenase - metabolism; Vesicular Acetylcholine Transport Proteins - genetics; Vesicular Acetylcholine Transport Proteins - metabolism; intrapancreatic ganglia; fatty infiltration; pancreatic steatosis; tissue clearing; autonomic innervation

The pancreas consists of both the exocrine (acini and ducts) and endocrine (islets) compartments to participate in and regulate the body’s digestive and metabolic activities. These activities are subjected to neural modulation, but characterization of the human pancreatic afferent and efferent nerve...