4-Hydroxycinnamate Lowers Plasma and Hepatic Lipids without Changing Antioxidant Enzyme Activities

• Published in: Annals of nutrition and metabolism Vol. 47; no. 3; pp. 144 - 151
• Main Authors: Lee, Jeong-Sun, Bok, Song-Hae, Park, Yong Bok, Lee, Mi-Kyung, Choi, Myung-Sook
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 2003; Karger
• Subjects: Animals; Anticholesteremic Agents - pharmacology; Antioxidants - metabolism; Antioxidants - pharmacology; Biological and medical sciences; Body Weight - drug effects; Cholesterol, Dietary - pharmacology; Coumaric Acids - blood; Coumaric Acids - pharmacology; Eating - drug effects; Enzymes - drug effects; Feces - chemistry; Fundamental and applied biological sciences. Psychology; General aspects; Hydroxymethylglutaryl CoA Reductases - drug effects; Hydroxymethylglutaryl CoA Reductases - metabolism; Hypolipidemic Agents - pharmacology; Lipid Metabolism; Lipids - blood; Liver - drug effects; Liver - metabolism; Lovastatin - pharmacology; Male; Organ Size - drug effects; Original Paper; Propionates; Rats; Rats, Sprague-Dawley; Sterol O-Acyltransferase - drug effects; Sterol O-Acyltransferase - metabolism; Sterols - analysis; Thiobarbituric Acid Reactive Substances - metabolism; Vertebrates: anatomy and physiology, studies on body, several organs or systems; 4-Hydroxycinnamate; Cholesterol metabolism; Antioxidant enzymes; Rat; Liver; Rodentia; Lipids; Antioxidant; Metabolism; Feeding; Blood plasma; Vertebrata; Mammalia; Enzymatic activity; Animal
• DOI: 10.1159/000070037
• ISSN: 0250-6807

Background/Aims: The purpose of this study was to investigate the influence of 4-hydroxycinnamate (4-(OH)-C) supplement on the lipid metabolism and antioxidant system of rats fed a high-cholesterol diet. Methods: Three groups of rats were given a diet containing 1 g cholesterol/kg for 6 weeks. The control group only received a high cholesterol diet, whereas the other two groups received a diet including lovastatin or 4-(OH)-C (0.1 g/100 g). Results: The plasma total cholesterol concentration was significantly lowered by the 4-(OH)-C supplement, whereas the HDL-cholesterol level was higher in this group. The 4-(OH)-C supplement significantly lowered the hepatic cholesterol and triglycerides levels, respectively. Accumulation of hepatic lipid droplet was the highest in control group; however, it was decreased by supplementation of the 4-(OH)-C and the lovastatin. The hepatic HMG-CoA reductase activities were not significantly different between the groups, whereas the ACAT activity was significantly lowered in the lovastatin group. The 4-(OH)-C significantly lowered the hepatic TBARS content. And it did not alter the neutral sterol and total fecal sterol, however, the fecal acidic sterol was higher in the lovastatin and the 4-(OH)-C groups than in the control group. Conclusion: These results indicate that 4-(OH)-C was effective in lowering the plasma cholesterol and hepatic lipids.